Biofilm on Chest Drains After Thoracic Surgery: Clinical Impact and Antibiotic Resistance
NCT ID: NCT07228598
Last Updated: 2025-11-19
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
180 participants
OBSERVATIONAL
2025-10-01
2026-07-01
Brief Summary
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The main objectives are to evaluate the relationship between the duration of chest drain placement and the presence of biofilm, and to identify the antibiotic resistance profiles of microorganisms isolated from these biofilms. Secondary outcomes include the association between biofilm formation, postoperative infections (such as empyema or wound infection), and the length of hospital stay.
This study will be conducted at Ondokuz Mayıs University Faculty of Medicine, Department of Thoracic Surgery, in collaboration with the Department of Microbiology. The findings are expected to contribute to better understanding of optimal drain management and infection prevention strategies after thoracic surgery.
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Group 1 -Short Drain Duration (≤2 Days)
Participants whose thoracic chest drains were removed within 2 days after surgery. Drain tip samples from these patients will be analyzed for biofilm formation and microbiological culture.
Chest Drain Tip Sampling
No active intervention; routine chest drain removal followed by microbiological and biofilm analysis of drain tip samples.
Group 2 - Moderate Drain Duration (3-4 Days)
Participants whose thoracic chest drains remained in place for 3 to 4 days postoperatively. Drain tips will be examined for biofilm presence and bacterial growth patterns.
Chest Drain Tip Sampling
No active intervention; routine chest drain removal followed by microbiological and biofilm analysis of drain tip samples.
Group 3 - Long Drain Duration (≥5 Days)
Participants with chest drains in place for 5 days or longer. Biofilm formation, bacterial species identification, and antibiotic resistance profiles will be evaluated.
Chest Drain Tip Sampling
No active intervention; routine chest drain removal followed by microbiological and biofilm analysis of drain tip samples.
Interventions
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Chest Drain Tip Sampling
No active intervention; routine chest drain removal followed by microbiological and biofilm analysis of drain tip samples.
Eligibility Criteria
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Inclusion Criteria
* Undergoing elective thoracic surgery requiring chest drain placement
* Able and willing to provide written informed consent
Exclusion Criteria
* Emergency thoracic surgery
* Immunosuppressed patients (e.g., neutropenia, advanced malignancy, organ transplantation)
* Patients receiving systemic antibiotic therapy at the time of drain removal
* Drainage for empyema or pre-existing pleural infection
* Presence of extrathoracic infection focus
* Refusal or inability to provide informed consent
18 Years
ALL
No
Sponsors
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Caner İşevi, MD
OTHER
Responsible Party
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Caner İşevi, MD
Principal Investigator
Locations
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Ondokuz Mayis University Medical Faculty, Department of Thoracic Surgery
Samsun, Samsun, Turkey (Türkiye)
Countries
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Facility Contacts
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Other Identifiers
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B.30.2.ODM.0.20.08/600-660
Identifier Type: -
Identifier Source: org_study_id
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