Effectiveness of Chlorhexidine Wipe for Prevention of Multidrug-resistant Organisms in Intensive Care Unit Patients

NCT ID: NCT01989416

Last Updated: 2015-12-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

481 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-12-31

Study Completion Date

2015-04-30

Brief Summary

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The purpose of this study is to determine 2% chlorhexidine wipes are effective in preventing of colonization of multi-drug resistant bacteria in intensive care unit patients.

Detailed Description

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The purpose of this study is to evaluate the usefulness of bathing with chlorhexidine wipe to reduce the risks of multidrug resistant bacteria acquisition and hospital-acquired bloodstream infection among ICU patients

Conditions

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Antibiotic Resistant Infection

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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Soap bathing

ICU patients will be bathing with soap at least once daily

Group Type PLACEBO_COMPARATOR

Soap

Intervention Type DRUG

The ICU patients will be bathing with Soap

2% chlorhexidine wipes

Use 2% chlorhexidine wipes to clean the patient at least once daily

Group Type EXPERIMENTAL

2% chlorhexidine wipe

Intervention Type DRUG

The ICU patients will be bathing with 2% chlorhexidine wipe

Interventions

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2% chlorhexidine wipe

The ICU patients will be bathing with 2% chlorhexidine wipe

Intervention Type DRUG

Soap

The ICU patients will be bathing with Soap

Intervention Type DRUG

Other Intervention Names

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chlorhexidine wipe Control soap

Eligibility Criteria

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Inclusion Criteria

* Age \> 18 years
* Admission in critical care unit eg. ICU, respiratory care unit, Cardiac care unit with in 24 hours
* Expected duration of critical care unit admission \> 48 hours

Exclusion Criteria

* History of chlorhexidine allergy
Minimum Eligible Age

18 Years

Maximum Eligible Age

95 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Mahidol University

OTHER

Sponsor Role lead

Responsible Party

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Adhiratha Boonyasiri

Doctor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Adhiratha Boonyasiri, MD

Role: PRINCIPAL_INVESTIGATOR

Mahidol University

Locations

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Faculty of Medicine Siriraj Hospital, Mahidol University

Bangkok, Bangkok, Thailand

Site Status

Countries

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Thailand

References

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Boonyasiri A, Thaisiam P, Permpikul C, Judaeng T, Suiwongsa B, Apiradeewajeset N, Fakthongphan T, Suddee S, Laoagtipparos W, Thamlikitkul V. Effectiveness of Chlorhexidine Wipes for the Prevention of Multidrug-Resistant Bacterial Colonization and Hospital-Acquired Infections in Intensive Care Unit Patients: A Randomized Trial in Thailand. Infect Control Hosp Epidemiol. 2016 Mar;37(3):245-53. doi: 10.1017/ice.2015.285.

Reference Type DERIVED
PMID: 26894621 (View on PubMed)

Other Identifiers

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567-2556-EC4

Identifier Type: -

Identifier Source: org_study_id