Examining Heavy Metal Exposure and Respiratory Health in Young Adult Electronic Cigarette Users

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-10-22

Study Completion Date

2026-05-31

Brief Summary

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This study investigates heavy metal exposure in young adults who use electronic cigarettes.

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Detailed Description

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PRIMARY OBJECTIVES:

I. Identify and quantify heavy metals (HM) concentration in the saliva of e-cigarette users.

II. Examine changes in pulmonary functioning and HM concentration pre/post vaping.

III. Examine the association between vaping intensity and HM concentration in the saliva of e-cigarette users.

OUTLINE: This is an observational study.

Participants vape their own electronic cigarette device as much or as little as they like over 30 minutes on study. Participants also undergo saliva sample collection, spirometry to measure respiratory function, and complete questionnaires.

Conditions

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Heavy Metal Exposure From Vaping

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Observational

Participants vape their own electronic cigarette device as much or as little as they like over 30 minutes on study. Participants also undergo saliva sample collection, spirometry to measure respiratory function, and complete questionnaires.

Non-Interventional Study

Intervention Type OTHER

Non-Interventional Study

Interventions

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Non-Interventional Study

Intervention Type OTHER

Other Intervention Names

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Non-Interventional Observational Study

Eligibility Criteria

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Inclusion Criteria

* Aged 18-29 years
* Established electronic cigarette (EC) user (participant uses ECs on a daily/weekly basis \[used on ≥ 5 days in past 30-days\] for the past 3 months)
* Willing to abstain from nicotine for at least 12 hours before the laboratory visit
* Willing to not eat food or drink water/beverages for at least 30 minutes before the laboratory visit \[required for salivary collection\]
* Utilize 4th generation EC products (pod-mod or disposable EC products; e.g., JUUL, Hyde)
* Must be able to read and write in English

Exclusion Criteria

* Recently COVID-19+ (defined as a positive test in the past 30 days) or a recent COVID-19 hospitalization (within the past 6 months)
* Attempting to quit the use of ECs
* Past 30-day use of other tobacco products (e.g., combustible cigarettes)
* Is pregnant, planning on becoming pregnant and/or breastfeeding \[will be verified using a urine pregnancy test\]
* Self-reported severe or significant psychological and/or psychiatric conditions \[e.g., not currently receiving treatment/medication; only past and/or stable conditions will be allowed\]
* A history of cardiac events and/or distress within the past 3 months
* Diagnosed with a chronic, serious lung disease or current infection (e.g., pneumonia, pulmonary edema)
* Are deaf, hard of hearing, or have a severe motor disability

Minimum Eligible Age

18 Years

Maximum Eligible Age

29 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes