Impact of Chronic and Acute Caffeine Intake on the Hematopoietic System

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-10-31

Study Completion Date

2028-06-30

Brief Summary

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This study investigates how caffeine intake affects blood stem and progenitor cells in healthy adults.

The trial will compare people who regularly consume caffeine with those who consume very little or none. All participants will receive a single 200 mg caffeine tablet (similar to one cup of coffee) under fasting conditions. Blood samples will be collected before and three hours after caffeine intake.

The study will assess whether caffeine influences the mobilization of blood stem and progenitor cells from the bone marrow into the bloodstream. It will also examine the effects of caffeine on the function, gene activity, and metabolism of blood cells.

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Detailed Description

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Conditions

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Healthy Adults; Hematopoietic System; Caffeine

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

This is a single-group, open-label study in which all participants receive a single oral dose of 200 mg caffeine under fasting conditions. Blood samples are collected before and three hours after caffeine intake to assess mobilization, function, gene expression, and metabolic profile of hematopoietic stem and progenitor cells.

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Caffeine intervention

200mg Caffeine

Group Type EXPERIMENTAL

Caffeine (200 mg)

Intervention Type OTHER

Participants receive a single oral dose of 200 mg caffeine under fasting conditions. Blood samples are collected before and three hours after intake to evaluate effects on hematopoietic stem and progenitor cells, including mobilization, function, gene expression, and metabolism.

Interventions

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Caffeine (200 mg)

Participants receive a single oral dose of 200 mg caffeine under fasting conditions. Blood samples are collected before and three hours after intake to evaluate effects on hematopoietic stem and progenitor cells, including mobilization, function, gene expression, and metabolism.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Able to give consent.
* Healthy adults aged ≥ 18 years.
* Regular caffeine consumers (≥1 coffee cup/day or ≥1 energy drink/day) or non-consumers (≤1 cup/month and ≤1 energy drink/month) for at least 6 months.
* Willingness to comply with fasting requirements and study procedures.

Exclusion Criteria

* Chronic illnesses or medication use affecting metabolism, including metabolic disorders (e.g., diabetes, thyroid dysfunction, metabolic syndrome).
* Personal history of cancer.
* Personal history of hematological disorders.
* History of radiation therapy.
* Known caffeine hypersensitivity or intolerance.
* Known immunosuppression.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes