Evaluation of CT-XPI

NCT ID: NCT07192133

Last Updated: 2026-02-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

PHASE2

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2026-01-26

Study Completion Date

2026-12-31

Brief Summary

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The goal of this clinical trial is to learn if a new computed tomography (CT) lung perfusion imaging method is as effective as standard of care (SOC) CT imaging. The main question it aims to answer is:

* Does the new contrast-free method provide more information about lung perfusion than SOC?

Participants will undergo a 30 minute chest CT.

Detailed Description

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The purpose of the study is to evaluate X-ray Pulsatility Index using prospectively acquired dynamic CT, which is different from conventional static CT scans.

The primary objective of this study is to collect dynamic CT scan data with human participants using high frame rate imaging methods to produce a map of lung perfusion.

Conditions

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CT Scan Computed Tomography

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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CT scan

Participants undergoing a CT

Group Type EXPERIMENTAL

CT scan

Intervention Type DIAGNOSTIC_TEST

Dynamic contrast-free chest CT scan

Interventions

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CT scan

Dynamic contrast-free chest CT scan

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Age 18 years or older
* Able to sign and date the informed consent form
* Will undergo a clinically-indicated CT exam of the head, neck, chest, abdomen, pelvis, or extremities

Exclusion Criteria

* Pregnant or lactating
* In need of urgent or emergent care
* Have any conditions that, in the opinion of the PI or designee, would interfere with the evaluation of the results or constitute a health hazard for the participant
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Wisconsin, Madison

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Matthew Smith, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Wisconsin, Madison

Locations

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University of Wisconsin - Madison

Madison, Wisconsin, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Radiology Studies

Role: CONTACT

608-282-8349

Other Identifiers

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SMPH/RADIOLOGY/RADIOLOGY

Identifier Type: OTHER

Identifier Source: secondary_id

AS

Identifier Type: OTHER

Identifier Source: secondary_id

Protocol Version 1/18/2025

Identifier Type: OTHER

Identifier Source: secondary_id

2025-0586

Identifier Type: -

Identifier Source: org_study_id

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