Evaluation of Mean Platelet Volume and Systemic Inflammatory Response Index (SIRI) in Patients of Acute Coronary Syndrome

NCT ID: NCT07149883

Last Updated: 2025-09-02

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Total Enrollment: 300 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2025-09-20
• Study Completion Date: 2026-10-20

Brief Summary

To assess the diagnostic and prognostic significance of MPV and SIRI in patients presenting with acute coronary syndrome.(STEMI/NSTEMI/UN STABLE ANGINA)

Detailed Description

Acute coronary syndrome (ACS), which includes unstable angina, non-ST elevation myocardial infarction (NSTEMI), and ST elevation myocardial infarction (STEMI), is a leading cause of hospitalization and death globally【1】. The pathophysiology of ACS involves plaque rupture, platelet activation, thrombus formation, and a significant inflammatory component【2】. Early diagnosis and accurate risk stratification are critical for improving patient outcomes and guiding therapy.

Mean Platelet Volume (MPV) is a simple, cost-effective parameter obtained from the complete blood count. It reflects platelet size and activity-larger platelets are more reactive and thrombogenic. Studies have demonstrated that MPV is elevated in patients with ACS and may correlate with infarct size and poor prognosis【3,4】.

The systemic inflammatory response plays a pivotal role in the destabilization of atherosclerotic plaques. Recently, novel inflammatory indices such as the Systemic Inflammatory Response Index (SIRI)-calculated as (neutrophil count × monocyte count) / lymphocyte count-have emerged as potential marker for cardiovascular risk. SIRI reflects the combined effect of pro-inflammatory and anti-inflammatory components of the immune system【5】. Elevated SIRI has been associated with adverse outcomes in various conditions, including stroke, cancer, and cardiovascular diseases【6,7】.

Despite the individual significance of MPV and SIRI, limited data are available on their combined utility in ACS patients. Evaluating both markers together may provide a more comprehensive picture of the thrombo-inflammatory state and help identify high-risk patients at admission, facilitating more personalized care【8】.

Conditions

Coronary Artery Disease

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: PROSPECTIVE

Interventions

Complete blood count

Complete blood count

Intervention Type: OTHER

ECHO

device that used to evaluate the cardiac function

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

• Patients ≥ 18 years old.

• Diagnosed with acute coronary syndrome (unstable angina, NSTEMI, STEMI).
• Admission within 24 hours of symptom onset.

Exclusion Criteria

• o Active infection or chronic inflammatory diseases.

• Known hematological disorders or malignancy.
• Chronic liver or renal failure.
• Recent surgery or trauma (< 1 month).
• Patients with rheumatic heart disease
• Patient refusal

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Assiut University

OTHER

Sponsor Role: lead

Responsible Party

Asmaa salama ahmed omar

Doctor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Ghada Hassan, Professor

Role: STUDY_DIRECTOR

Assuit university hospital

Hanan Sharaf, Professor

Role: STUDY_DIRECTOR

Assuit university hospital

Central Contacts

Asmaa Salama ahmed omar, Resident doctor

Role: CONTACT

asmaasalamaahmed4@gmail.com

+01067687469 ext. 01006876891

References

Libby P. Inflammation in atherosclerosis. Nature. 2002 Dec 19-26;420(6917):868-74. doi: 10.1038/nature01323.

Reference Type: BACKGROUND

PMID: 12490960 (View on PubMed)

Anderson JL, Morrow DA. Acute Myocardial Infarction. N Engl J Med. 2017 May 25;376(21):2053-2064. doi: 10.1056/NEJMra1606915. No abstract available.

Reference Type: BACKGROUND

PMID: 28538121 (View on PubMed)

Other Identifiers

MPV and SIRI in of ACS

Identifier Type: -

Identifier Source: org_study_id