Effects of a Long-term Exercise Training Program on the Functional Capacity and Health-related Quality of Life in Inpatients With Psychotic Disorders

NCT ID: NCT07113119

Last Updated: 2025-08-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

48 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-08-04

Study Completion Date

2025-08-15

Brief Summary

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Mental health represents a fundamental dimension of overall well-being, exerting a significant influence on mortality rates, health-related quality of life (HRQoL), levels of disability, and the strain on healthcare systems. As the interest in mental wellness continues to grow, exercise training (ET) has become increasingly recognized as a validated and effective intervention for individuals experiencing mental health challenges. An expanding body of research underscores the adverse effects of physical inactivity, reinforcing the role of exercise as a viable therapeutic strategy.

Well-structured ET interventions have consistently demonstrated benefits across multiple domains, including improvements in physical health, reductions in cardiovascular risk, and enhancements in psychological constructs such as depression, self-esteem, resilience, and self-efficacy. However, the majority of prior studies have been limited to relatively short durations-typically ranging from 4 to 24 weeks, with an average of about 12 weeks. A significant gap in the literature persists regarding the long-term implementation and effectiveness of ET programs, particularly in populations with severe mental illness. Additionally, the small sample sizes commonly seen in previous studies restrict the statistical robustness and generalizability of their outcomes.

The aim of the randomized control trial is to examine whether an 1-year mixed type exercise training program within the hospital setting will improve functional capacity and health-related quality of life. Forty- eight participants will be randomly allocated into two groups: Group A (Exercise group) will receive 3 exercise sessions per week for 1-year and Group B (Control Group) will continue their usual care, without participating in organized exercise programs. Prior to the group random allocation, part of the assessment at the baseline and 1 year follow-up will include lower extremity strength test, muscle power using a dynamometer, aerobic capacity test, balance test, body positioning and health- related quality of life.

Detailed Description

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Conditions

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Psychotic Disorder

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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GROUP A: EXERCISE GROUP

Exercise group: 1-year mixed-type exercise training program

Group Type EXPERIMENTAL

Exercise intervention

Intervention Type OTHER

Patients that will be randomly assigned in the group A will be invited to attent 1-year exercise sessions, with frequency 3 sessions per week. The program included 30 minutes of Pilates exercises, strengthening, balance and flexibility exercises, which are performed with rubber bands, mobility sticks and balls.

GROUP B: CONTROL GROUP

Control Group: 1-year normal physical activity, without participating in organized sports programs

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Exercise intervention

Patients that will be randomly assigned in the group A will be invited to attent 1-year exercise sessions, with frequency 3 sessions per week. The program included 30 minutes of Pilates exercises, strengthening, balance and flexibility exercises, which are performed with rubber bands, mobility sticks and balls.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* being an adult
* inpatient with a diagnosis of psychotic syndrome
* on stable medication
* controlled as far as psychosis is concerned
* consenting to participate

Exclusion Criteria

* adolescents
* with other diagnoses
* not on stable medication
* in an unstable condition
* unwilling to participate in the study
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Aristotle University Of Thessaloniki

OTHER

Sponsor Role lead

Responsible Party

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Evangelia Kouidi

Professor of Sports Medicine

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Sports Medicine Laboratory, Aristotle University of Thessaloniki

Thessaloniki, Thermi, Greece

Site Status RECRUITING

Countries

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Greece

Central Contacts

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Evangelia Kouidi

Role: CONTACT

+302310992189

Theochari Victoria

Role: CONTACT

Facility Contacts

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Evangelia Kouidi

Role: primary

+302310992189

Theochari Victoria

Role: backup

Other Identifiers

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EH-44/2021

Identifier Type: -

Identifier Source: org_study_id

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