Assessment of Right Ventricular Function After Acute Pulmonary Embolism: a Comparison of Speckle Tracking Strain and Conventional Echocardiographic Parameters

NCT ID: NCT07107347

Last Updated: 2025-08-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-09-30

Study Completion Date

2028-03-31

Brief Summary

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Echocardiographic Assessment:

Performed within 24h of PE diagnosis Conventional parameters: TAPSE, RV FAC, RV/LV ratio, tricuspid S', PASP STE parameters: RV free wall longitudinal strain (RVFWS), global longitudinal strain (GLS) if feasible All measurements averaged over 3 cardiac cycles (sinus) or 5 (AF)

Follow-up data:

ICU/hospital LOS Need for vasopressors/mechanical ventilation In-hospital and 30-day mortality

Detailed Description

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the study targets patient with acute pulmonary embolism confirmed by CTPA, without hemodynamic instability. within the first 24 hours echocardiography will be conducted, assessment of RV function by conventional measures eg, TAPSE, S', FCA and speckle tracking strain echocardiography.

compare the results and its sensitivity in prediction of clinical outcomes, that will be assessed by follow up the patients for one month regarding length of hospital stay, oxygen/ventilatory support, hemodynamics support and 30 day mortality.

Conditions

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Acute Pulmonary Embolism (PE)

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

1. Adults ≥18 years.
2. Confirmed acute PE (via CT pulmonary angiography).(4,6)
3. Echocardiography performed within 24 hours of diagnosis.

Exclusion Criteria

1. Pre-existing significant RV dysfunction (e.g., due to chronic pulmonary hypertension, cor pulmonale or congenital heart disease).
2. History of coronary artery disease.
3. Impaired LV systolic function, ejection fraction \<50%.
4. Moderate to severe valvular heart disease.
5. Prior document of an episode of pulmonary embolism.
6. Poor acoustic window.
7. Hemodynamic instability
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Assiut University

OTHER

Sponsor Role lead

Responsible Party

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Doaa Roshdy Abdul Satar Mohamed

assistant lecturer

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Assiut University Hospital

Asyut, Asyut Governorate, Egypt

Site Status

Countries

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Egypt

Central Contacts

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Doaa Roshdy, assistant lecturer

Role: CONTACT

+201024588594

Facility Contacts

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Doaa Roshdy

Role: primary

01024588594

Other Identifiers

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STE in pulmonary embolism

Identifier Type: -

Identifier Source: org_study_id

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