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Assessment of Right Ventricular Function After Acute Pulmonary Embolism Using Speckle Tracking Echocardiography

NCT ID: NCT04609605

Last Updated: 2020-11-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

68 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-12-31

Study Completion Date

2022-01-31

Brief Summary

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1. To asses regional RV function in patients presented with acute pulmonary embolism using speckle tracking echocardiography
2. To evaluate its relationship to long term mortality.

Detailed Description

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Pulmonary embolism (PE) is the third most common cardiovascular cause of death after myocardial infarction and stroke . The incidence of PE has been increasing ,with significant associated mortality; a recent registry of PE patients reported a mortality rate \> 10% at 30 days. There are a number of emerging contemporary PE therapies, including thrombolysis, catheter intervention and surgery. Early and accurate identification of PE in patients is therefore critical. A transthoracic echocardiogram (TTE) may help when there is a clinical suspicion for PE, and its use in confirmed PE is widely recommended . A number of right atrial (RA) and right ventricular (RV) parameters have been shown to be abnormal in patients with PE . In addition, RA and RV enlargement portends a worse prognosis in these patients .

Conditions

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Pulmonary Embolism

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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patients with acute pulmonary embolism

speckle tracking echocardiography for patient with acute pulmonary embolism

Group Type EXPERIMENTAL

speckle tracking echocardiography

Intervention Type DEVICE

speckle tracking echocardiography of right ventricle

Interventions

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speckle tracking echocardiography

speckle tracking echocardiography of right ventricle

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

1. clinical diagnosis of acute pulmonary embolism
2. Age: 20 - 70 years.

Exclusion Criteria

1. coronary artery disease
2. patient of Atrial fibrillation.
3. Patient of impaired RV function due to chest disease (Cor-pulmonale)
4. patient with impaired Ejection fraction (EF) \<50%
5. Moderate to severe valvular heart disease.
6. Atrio-ventricular conduction disturbance.
7. Poor echogenicity
Minimum Eligible Age

20 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Assiut University

OTHER

Sponsor Role lead

Responsible Party

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Mahmoud Said Rashwan

doctor

Responsibility Role PRINCIPAL_INVESTIGATOR

Central Contacts

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Mahmoud Said rashwan, master degree of cardiology

Role: CONTACT

[email protected]
01007949203

References

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Wendelboe AM, Raskob GE. Global Burden of Thrombosis: Epidemiologic Aspects. Circ Res. 2016 Apr 29;118(9):1340-7. doi: 10.1161/CIRCRESAHA.115.306841.

Reference Type BACKGROUND
PMID: 27126645 (View on PubMed)

McConnell MV, Solomon SD, Rayan ME, Come PC, Goldhaber SZ, Lee RT. Regional right ventricular dysfunction detected by echocardiography in acute pulmonary embolism. Am J Cardiol. 1996 Aug 15;78(4):469-73. doi: 10.1016/s0002-9149(96)00339-6.

Reference Type BACKGROUND
PMID: 8752195 (View on PubMed)

Fields JM, Davis J, Girson L, Au A, Potts J, Morgan CJ, Vetter I, Riesenberg LA. Transthoracic Echocardiography for Diagnosing Pulmonary Embolism: A Systematic Review and Meta-Analysis. J Am Soc Echocardiogr. 2017 Jul;30(7):714-723.e4. doi: 10.1016/j.echo.2017.03.004. Epub 2017 May 9.

Reference Type BACKGROUND
PMID: 28495379 (View on PubMed)

Trivedi SJ, Altman M, Stanton T, Thomas L. Echocardiographic Strain in Clinical Practice. Heart Lung Circ. 2019 Sep;28(9):1320-1330. doi: 10.1016/j.hlc.2019.03.012. Epub 2019 Apr 12.

Reference Type BACKGROUND
PMID: 31064715 (View on PubMed)

Other Identifiers

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speckle tracking in PE

Identifier Type: -

Identifier Source: org_study_id