The Effect of Heat Exposure on Physiological Markers

NCT ID: NCT07064512

Last Updated: 2025-07-17

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 11 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2021-01-11
• Study Completion Date: 2021-03-12

Brief Summary

This study is the first to examine the effects of core temperature elevation on kynurenine pathway (KP) metabolites in healthy young males. It was hypothesized that rise in core temperature due to both pasive heating and exercise will initiate a stress response, affecting the concentration of KP metabolites. Additionally, it was expected that the exercise would produce more pronounced effects due to the increased cardiovascular, mechanical, and metabolic demands associated with it. Thus, the the main purpose of the present study was to investigate and to compare the effects of two distinct heat stress modalities on KP metabolites.

Conditions

Healthy Adult Male

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: SINGLE

Study Groups

Exogenous heating

Healthy young subjects participated received exogenous heating modality, where the participants sat immersed in a water bath at 43.5 ± 0.5°C and remained submerged until rectal temperature reached 39°C.

Group Type: EXPERIMENTAL

Exogenous heating

Intervention Type: OTHER

Hot-water immersion was used as the exogenous heating modality, where the participants sat immersed in a water bath at 43.5 ± 0.5°C and remained submerged until rectal temperature reached 39°C.

Endogenous heating

Healthy young subjects participated received endogenous heating modality, the participant cycled at 60% of his VO2max until rectal temperature reached 39°C

Group Type: EXPERIMENTAL

Endogenous heating

Intervention Type: OTHER

Exercise was used as the endogenous heating modality, the participant cycled at 60% of his VO2max until rectal temperature reached 39°C

Interventions

Endogenous heating

Exercise was used as the endogenous heating modality, the participant cycled at 60% of his VO2max until rectal temperature reached 39°C

Intervention Type: OTHER

Exogenous heating

Hot-water immersion was used as the exogenous heating modality, where the participants sat immersed in a water bath at 43.5 ± 0.5°C and remained submerged until rectal temperature reached 39°C.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• healthy adults;
• age between 18 - 36 years;
• physically active (exercising 2-3 times per week);
• non-smoking.

Exclusion Criteria

• a body mass index (BMI) > 30 kg/m2;
• neurological, cardiovascular, metabolic, and/or inflammatory diseases, or conditions that could be worsened by exposure to interventions and that could affect experimental variables;
• involvement in temperature manipulation program for ≥ 3 months.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 36 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: Yes

Sponsors

Lithuanian Sports University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Lithuanian Sports University

Kaunas, , Lithuania

Countries

Lithuania

Other Identifiers

LithuananianSportsU-24

Identifier Type: -

Identifier Source: org_study_id