Correlation Between Acne Vulgaris and Lipid Profile Among Young Adults in Sohag Governorate

NCT ID: NCT07062081

Last Updated: 2025-07-14

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Clinical Phase: NA
• Total Enrollment: 100 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-08-01
• Study Completion Date: 2026-01-30

Brief Summary

Acne vulgaris is the most common skin condition affecting late adolescents worldwide.1 The prevalence of acne is said to be 85% in adults aged 12 to 25 years.2 Almost all teenagers between 15 and 17 years report having some degree of acne.3 Estimates of the lifetime occurrence of acne in the literature range from 0.1%4 to as high as 85.1%5 in the general population, depending on the age range, region, and method of sampling. Overall, acne is more common in women,8,9 but in some literature the prevalence is approximately equal in men and women.10,11

Detailed Description

Acne vulgaris is a multifactorial disorder of the pilosebaceous unit, resulting from sebum overproduction, follicular hyperkeratinization, inflammation, and bacterial colonization of hair follicles by Propionibacterium acnes. The sebaceous gland is controlled primarily by hormonal stimulation. In this way, the hormonal effect on sebum secretion is a key to the pathogenesis of acne.12-16 During puberty, alteration of the sebum component, called dysseborrhea, stress, irritation, cosmetics, and potential dietary factors lead to the formation of acne lesions.16 Changes in sebum secretion are considered to be an important factor of acne. In this way, increased sebum secretion can induce acne occurrence.17 Increasing evidence, in essence, indicates that changes in lipid profile are strongly related to acne occurrence. Accordingly, further information and awareness campaigns are needed to emphasize the role of balanced lipid metabolism to control acne. Although a correlation between the incidence of acne and lipid profile levels has been observed before, it must be documented in each population with etiological characteristics. Minimal reports are available on the relationship between plasma lipids and acne in our country. Hence, we aim to establish this study to estimate the presence of lipid alteration in acne patients.

Conditions

Acne Vulgaris

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: SCREENING
• Blinding Strategy: NONE

Interventions

lipid profile

The blood samples were taken to measure lipid profile levels as triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL), and high-density lipoprotein cholesterol (HDL) and VLDL values.

Intervention Type: DIAGNOSTIC_TEST

Eligibility Criteria

Inclusion Criteria

• age- and sex-matched healthy volunteers, not taking any medicine, and having no personal or family history of acne.

Exclusion Criteria

• : reluctance to take part in the study, pregnancy or lactation

• intake of oral contraception or hormone therapy, history of taking any medications that affect lipid metabolism or oral isotretinoin
• and systemic diseases that affect the metabolism of lipids, such as uncontrolled diabetes, hypothyroidism, nephrotic syndrome, end-stage renal failure, HIV, familial hypercholesterolemia, and metabolic syndrome.

• Minimum Eligible Age: 12 Years
• Maximum Eligible Age: 45 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Sohag University

OTHER

Sponsor Role: lead

Responsible Party

Hager Ali Dardier

demonostrator at family medicine department

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Sohag university Hospital

Sohag, , Egypt

Countries

Egypt

Central Contacts

Hager A dardier, demonastrator

Role: CONTACT

hager.dardir@med.sohag.edu.eg

01129977680

hanan A metwaly, professor

Role: CONTACT

Facility Contacts

Magdy M Amin, professor

Role: primary

References

Degitz K, Ochsendorf F. Pharmacotherapy of acne. Expert Opin Pharmacother. 2008 Apr;9(6):955-71. doi: 10.1517/14656566.9.6.955.

Reference Type: BACKGROUND

PMID: 18377339 (View on PubMed)

Gibbs S. Skin disease and socioeconomic conditions in rural Africa: Tanzania. Int J Dermatol. 1996 Sep;35(9):633-9. doi: 10.1111/j.1365-4362.1996.tb03687.x.

Reference Type: BACKGROUND

PMID: 8876289 (View on PubMed)

Dreno B. Treatment of adult female acne: a new challenge. J Eur Acad Dermatol Venereol. 2015 Jun;29 Suppl 5:14-9. doi: 10.1111/jdv.13188.

Reference Type: BACKGROUND

PMID: 26059821 (View on PubMed)

Collier CN, Harper JC, Cafardi JA, Cantrell WC, Wang W, Foster KW, Elewski BE. The prevalence of acne in adults 20 years and older. J Am Acad Dermatol. 2008 Jan;58(1):56-9. doi: 10.1016/j.jaad.2007.06.045. Epub 2007 Oct 22.

Reference Type: BACKGROUND

PMID: 17945383 (View on PubMed)

Other Identifiers

Soh-Med-25-06-18MS

Identifier Type: -

Identifier Source: org_study_id