Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
30 participants
OBSERVATIONAL
2013-11-30
2015-07-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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Healthy Group
The subjects in this group do not have a history of acne.
No interventions assigned to this group
Acne Group, Topical Retinoid
These subjects have been prescribed a topical retinoid for their acne. They will participate in the study for a period of 1 month.
Tretinoin or Adapalene
Subjects will apply a pea sized amount of topical retinoid cream once daily at night for 30 days. Subjects will return for a follow-up visit.
Acne Group, Isotretinoin
These subjects have been prescribed isotretinoin for their acne. They will participate in the study for a period of 5-6 months.
Isotretinoin
Subjects will take one pill once daily for 5 months. Subjects will return after 1 month and after 4-5 months of treatment for skin lipid profiling.
Interventions
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Tretinoin or Adapalene
Subjects will apply a pea sized amount of topical retinoid cream once daily at night for 30 days. Subjects will return for a follow-up visit.
Isotretinoin
Subjects will take one pill once daily for 5 months. Subjects will return after 1 month and after 4-5 months of treatment for skin lipid profiling.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* have been prescribed tretinoin OR isotretinoin
Exclusion Criteria
* those who used tretinoin or other topical retinoid within two weeks of starting the study
* those with seborrheic dermatitis, rosacea, or polycystic ovary syndrome
* those who are pregnant, prisoners, or cognitively impaired
12 Years
30 Years
ALL
Yes
Sponsors
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University of California, Davis
OTHER
Responsible Party
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Principal Investigators
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Raja K Sivamani, MD
Role: PRINCIPAL_INVESTIGATOR
UC Davis
Locations
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Dermatology Research Area
Davis, California, United States
UC Davis Department of Dermatology
Sacramento, California, United States
Countries
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References
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Thody AJ, Shuster S. Control and function of sebaceous glands. Physiol Rev. 1989 Apr;69(2):383-416. doi: 10.1152/physrev.1989.69.2.383.
Blume U, Verschoore M, Poncet M, Czernielewski J, Orfanos CE, Schaefer H. The vellus hair follicle in acne: hair growth and sebum excretion. Br J Dermatol. 1993 Jul;129(1):23-7. doi: 10.1111/j.1365-2133.1993.tb03306.x.
Zouboulis CC, Baron JM, Bohm M, Kippenberger S, Kurzen H, Reichrath J, Thielitz A. Frontiers in sebaceous gland biology and pathology. Exp Dermatol. 2008 Jun;17(6):542-51. doi: 10.1111/j.1600-0625.2008.00725.x.
Doshi A, Zaheer A, Stiller MJ. A comparison of current acne grading systems and proposal of a novel system. Int J Dermatol. 1997 Jun;36(6):416-8. doi: 10.1046/j.1365-4362.1997.00099.x. No abstract available.
Morello AM, Downing DT, Strauss JS. Octadecadienoic acids in the skin surface lipids of acne patients and normal subjects. J Invest Dermatol. 1976 May;66(5):319-23. doi: 10.1111/1523-1747.ep12482300.
Related Links
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University of California-Davis Department of Dermatology Clinical Research
Other Identifiers
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531506
Identifier Type: -
Identifier Source: org_study_id
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