Effect of Systemic Isotretinoin on Serum Irisin Level in Acne Vulgaris Patients
NCT ID: NCT05869188
Last Updated: 2024-12-09
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
60 participants
INTERVENTIONAL
2023-06-01
2024-01-01
Brief Summary
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The severity of the disease ranges from mild comedonal acne to severe nodulocystic acne which can be permanently disfiguring.In addition to the physical lesions, the disease can have a profound psychologic impact, contributing to low self-esteem, depression and anxiety.In addition to the physical lesions, the disease can have a profound psychologic impact, contributing to low self-esteem, depression and anxiety.
Detailed Description
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Its pathogenesis results from androgen-induced increased sebum production, altered keratinization, inflammation of infundibular epithelium and bacterial colonisation of hair follicles by Propionibacterium acne
There are several treatment modalities for acne vulgaris including topical like topical antibiotics, topical benzoyl peroxide, topical azelaic acid and topical retinoids. Systemic therapy like antibiotics, hormonal therapy and isotretinoin .
Adipokines may have a role in the pathogenesis of acne vulgaris and are associated with acne severity. Irisin, a hormone -like myokine, is one of the adipokines with anti- inflammatory and anti-oxidant effects
There is limited evidence for physical modalities (e.g., laser therapy, light therapy, chemical peels) and complementary therapies (e.g., purified bee venom, low-glycemic-load diet, tea tree oil) .
isotretinoin (13-cis retinoic acid) is the most potent known inhibitor of sebum production. The multiple modes of action for isotretinoin includs suppression of sebaceous gland activity, normalization of the pattern of keratinization within the sebaceous gland follicle, inhibition of inflammation and reduction of growth of Propionibacterium acne .
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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Pateints with Moderate Acne
20 patients affected by Acne and More than half of the face is involved. Many papules and pustules, many open or closed comedones. One nodule may be present.
Isotretinoin
* Evaluate serum irisin level in acne vulgaris and compare it with healthy control .
* Evaluate the effect of systemic isotretinoin on serum irisin in acne vulgaris patients .
Pateints with Severe Acne
20 patients affected by Acne and Entire face is involved, covered with many papules and pustules, open or closed comedones and rare nodules
Isotretinoin
* Evaluate serum irisin level in acne vulgaris and compare it with healthy control .
* Evaluate the effect of systemic isotretinoin on serum irisin in acne vulgaris patients .
control
20 Health participants
Isotretinoin
* Evaluate serum irisin level in acne vulgaris and compare it with healthy control .
* Evaluate the effect of systemic isotretinoin on serum irisin in acne vulgaris patients .
Interventions
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Isotretinoin
* Evaluate serum irisin level in acne vulgaris and compare it with healthy control .
* Evaluate the effect of systemic isotretinoin on serum irisin in acne vulgaris patients .
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Clinical diagnosis of acne Disease
* Patient not receive any treatment for acne vulgaris at least six months duration.
Exclusion Criteria
14 Years
40 Years
ALL
Yes
Sponsors
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South Valley University
OTHER
Responsible Party
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Nahed Mohammed Abou Elwfa
Resident
Principal Investigators
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Essra Abass, Lecturer
Role: PRINCIPAL_INVESTIGATOR
Clinical Pathology Department, Faculty of Medicine, South valley University
Locations
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Qena Hospital
Qina, , Egypt
Countries
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Other Identifiers
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Nahed Abouelwfa
Identifier Type: -
Identifier Source: org_study_id