Effect Of Nigella Sativa Oil for the Treatment of Hypertension

NCT ID: NCT07055763

Last Updated: 2025-07-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-03-17

Study Completion Date

2026-02-28

Brief Summary

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My research explores the antihypertensive effects of Nigella sativa (black seed) oil in managing high blood pressure. Hypertension is a growing global health concern, often insufficiently controlled by standard medications. Nigella sativa, known for its bioactive compound thymoquinone, possesses antioxidant, anti-inflammatory, and vasodilatory properties, making it a potential natural remedy for blood pressure regulation.

Detailed Description

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Conditions

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Hypertension

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

HEALTH_SERVICES_RESEARCH

Blinding Strategy

NONE

Study Groups

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Nigella sativa Oil Supplementation

Group Type EXPERIMENTAL

Nigella sativa (black seed)

Intervention Type COMBINATION_PRODUCT

Participants in Group 1 (intervention group) will receive Nigella sativa (black seed) oil at a dosage of 0.5 ml, administered orally twice daily-once before breakfast and once before bedtime-for a duration of 12 weeks. The oil, sourced from a standardized local supplier, is rich in thymoquinone, known for its antioxidant and vasodilatory properties. Blood pressure will be measured at baseline and biweekly intervals using a calibrated digital sphygmomanometer to monitor changes in systolic and diastolic values. Participants will also be monitored regularly for any adverse effects.

No Intervention (Control Group)

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Nigella sativa (black seed)

Participants in Group 1 (intervention group) will receive Nigella sativa (black seed) oil at a dosage of 0.5 ml, administered orally twice daily-once before breakfast and once before bedtime-for a duration of 12 weeks. The oil, sourced from a standardized local supplier, is rich in thymoquinone, known for its antioxidant and vasodilatory properties. Blood pressure will be measured at baseline and biweekly intervals using a calibrated digital sphygmomanometer to monitor changes in systolic and diastolic values. Participants will also be monitored regularly for any adverse effects.

Intervention Type COMBINATION_PRODUCT

Eligibility Criteria

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Inclusion Criteria

* Adults aged 30 to 70 years
* Diagnosed with mild to moderate hypertension (BP ≥140/90 mmHg)
* Willing to participate and provide written informed consent
* Not currently on any herbal or nutritional supplements

Exclusion Criteria

* History of smoking or alcohol consumption
* Pregnant, postmenopausal, or breastfeeding women
* Use of dietary supplements or medications containing antioxidants, caffeine, estrogen, or steroids
* Individuals engaging in regular vigorous physical exercise
* Those adding extra salt to their meals
* Known allergy to Nigella sativa or black seed oil
Minimum Eligible Age

30 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Superior University

OTHER

Sponsor Role lead

Responsible Party

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Muhammad Naveed Babur

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Bahria Town

Lahore, Punjab Province, Pakistan

Site Status

Countries

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Pakistan

Other Identifiers

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MSAHSW/Batch-Fall23/924

Identifier Type: -

Identifier Source: org_study_id

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