Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
40 participants
INTERVENTIONAL
2010-12-31
2011-09-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
TRIPLE
Study Groups
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• Plantago asiatica L. extract 5g
Plantago asiatica L. extract 5g
Liquid (80g) containing Plantago asiatica L. extract 5g
Plantago asiatica L. extract 10g
Plantago asiatica L. extract 10g
Liquid (80g) containing Plantago asiatica L. extract 10g
Plantago asiatica L. extract 20g
Plantago asiatica L. extract 20g
Liquid (80g) containing Plantago asiatica L. extract 20g
Placebo
Placebo
Liquid (80g) without Plantago asiatica L. extract
Interventions
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Plantago asiatica L. extract 5g
Liquid (80g) containing Plantago asiatica L. extract 5g
Plantago asiatica L. extract 10g
Liquid (80g) containing Plantago asiatica L. extract 10g
Plantago asiatica L. extract 20g
Liquid (80g) containing Plantago asiatica L. extract 20g
Placebo
Liquid (80g) without Plantago asiatica L. extract
Eligibility Criteria
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Inclusion Criteria
* BMI(Body mass index) between 25 and 33 kg/m2
* Total cholesterol between 200mg/dL and 250mg/dL OR Triglyceride between 150mg/dL and 220mg/dL OR LDL-cholesterol between 130mg/dL and 165mg/dL
Exclusion Criteria
* Subject who has taken medicines, Chinese medicines and Health/Functional Foods which can affect antioxidative biomarkers within 30days of screening visit
* Subject who is pregnant or breast feeding
* Subject who lost body weight over 4kg within 30days of screening visit
* Alcoholic
* Smoker
* Subject who takes excessive exercise (over 7hours/week)
* Subject who has hypertension(≥140/90mmHg), diabetes(fasting blood glucose ≥126mg/dL), kidney disease, hepatic disease or hyperthyroidism within 2years
* Subject who has an allergy to the ingredients of study product
30 Years
ALL
Yes
Sponsors
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Ministry for Food, Agriculture, Forestry and Fisheries, Korea
OTHER_GOV
Ewha Womans University
OTHER
Responsible Party
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Oran Kwon
Ph.D, Professor
Principal Investigators
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Oran Kwon, Ph.D
Role: PRINCIPAL_INVESTIGATOR
Ewha Womans University
Locations
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Ewha Womans University / Hanaro Medical Foundation
Seoul, , South Korea
Countries
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References
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Sun Y. Free radicals, antioxidant enzymes, and carcinogenesis. Free Radic Biol Med. 1990;8(6):583-99. doi: 10.1016/0891-5849(90)90156-d.
Liu X, Wu X, Huang H, Zhong S, Lai X, Cao L. [Herbalogical study on Plantago asiatica L]. Zhong Yao Cai. 2002 Jan;25(1):46-8. Chinese.
Choi SY, Jung SH, Lee HS, Park KW, Yun BS, Lee KW. Glycation inhibitory activity and the identification of an active compound in Plantago asiatica extract. Phytother Res. 2008 Mar;22(3):323-9. doi: 10.1002/ptr.2316.
Chung MJ, Park KW, Kim KH, Kim CT, Baek JP, Bang KH, Choi YM, Lee SJ. Asian plantain (Plantago asiatica) essential oils suppress 3-hydroxy-3-methyl-glutaryl-co-enzyme A reductase expression in vitro and in vivo and show hypocholesterolaemic properties in mice. Br J Nutr. 2008 Jan;99(1):67-75. doi: 10.1017/S0007114507798926. Epub 2007 Aug 15.
Xu C, Luo L, Tan RX. Antidepressant effect of three traditional Chinese medicines in the learned helplessness model. J Ethnopharmacol. 2004 Apr;91(2-3):345-9. doi: 10.1016/j.jep.2004.01.012.
Lee SJ. Korean folk medicine. Publishing center of Seoul National Unicersity, Seoul. P 130, 1966
Jeong CH, Bae YI, Shim KH, Choi JS. DPPH radical scavenging effect and antimicrobial activities of Plantain (Plantago asiatica L.) extracts. J Korean Soc Food Sci Nutr 33(10): 1601-1605, 2004
Other Identifiers
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PLA_Biofood
Identifier Type: -
Identifier Source: org_study_id