Pumpkin Seeds or Oil Lower Serum Triglyceride Levels in Individuals With Hyperlipidaemia
NCT ID: NCT07123844
Last Updated: 2025-08-14
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
COMPLETED
NA
159 participants
INTERVENTIONAL
2022-06-01
2023-11-03
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
This randomized controlled experimental study aimed to evaluate the effects of cholesterol-restricted diets enriched with pumpkin seeds and pumpkin seed oil on cardiovascular risk factors-specifically serum lipid profile (total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides), blood pressure, and anthropometric measurements (body weight, body mass index, body fat percentage, and fat mass)-in individuals with hyperlipidemia.
Research Questions:
Does the nutritional intervention lead to a reduction in serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglyceride (TG) levels, as well as an increase in high-density lipoprotein cholesterol (HDL-C) levels across all study groups?
Do the groups receiving diets enriched with pumpkin seeds or pumpkin seed oil show greater improvements in lipid profile (TC, LDL-C, TG) and a more pronounced increase in HDL-C compared to the control group?
Does the nutritional intervention result in reductions in body weight, BMI, body fat percentage, and fat mass in all study groups?
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Effect of Pumpkin Seed Oil or Pumpkin Seeds on Blood Pressure and Menopausal Symptoms in Postmenopausal Women
NCT02727036
Nigella Sativa Supplementation in Hyperlipidemia Treatment
NCT06890546
A Study on the Effects of Mastiha Oil in Adults With Hypertriglyceridemia
NCT06323252
Effect of Bergamot and Plant Sterols Extract on Serum Lipid Profile
NCT06929403
Effect of Sunflower Seed Consumption on Blood Cholesterol Levels in Adults
NCT07231367
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
The study hypothesizes that incorporating pumpkin seeds or pumpkin seed oil into a cholesterol-restricted diet will improve serum lipid parameters and blood pressure, and reduce anthropometric measurements.
Research Questions:
Primary Questions:
Does consumption of a cholesterol-restricted diet in individuals with hyperlipidemia result in statistically significant improvements in the serum lipid profile (i.e., decreases in TC, LDL-C, and TG, and increases in HDL-C)?
Do diets enriched with pumpkin seeds or pumpkin seed oil lead to greater improvements in these lipid parameters compared to a control group that only follows a cholesterol-restricted diet?
Secondary Questions:
Does the intervention (regardless of group) lead to reductions in anthropometric indices such as body weight, BMI, body fat percentage, and fat mass?
Are reductions in anthropometric measurements and improvements in blood pressure more pronounced in groups consuming diets enriched with pumpkin seeds or pumpkin seed oil compared to the control group?
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
pumpkin seed
30 g/day pumpkin seed and low cholesterol diet (28 days)
low cholesterol diet
low cholesterol diet
pumpkin seed oil
15 g/day pumpkin seed oil and low cholesterol diet (28 days)
low cholesterol diet
low cholesterol diet
control
low cholesterol diet (28 days)
low cholesterol diet
low cholesterol diet
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
low cholesterol diet
low cholesterol diet
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* Aged between 19 and 64 years
* Body mass index (BMI) between 25.0 and 30.0 kg/m²
* Triglyceride (TG) level \> 200 mg/dL
* Low-density lipoprotein cholesterol (LDL-C) between 130 and 190 mg/dL
* Fasting blood glucose \< 110 mg/dL
* Blood pressure below 140/90 mmHg
Exclusion Criteria
* Diagnosis of any systemic disease, including:
* Diabetes mellitus
* Hypertension
* Cancer
* Metabolic syndrome
* Chronic kidney disease
* Use of any medication that affects blood lipid, glucose, and pressure levels
* Presence of food allergies (e.g., to pumpkin seeds or oil)
* Current or recent nutritional treatment or dietary therapy
* Pregnancy or breastfeeding
* Diagnosed psychiatric disorders
* Known congenital metabolic disorders
19 Years
64 Years
ALL
No
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
Okan University
OTHER
Kastamonu University
OTHER
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Kevser Karli
Principal Investigator
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
Kastamonu Training and Research Hospital
Kastamonu, , Turkey (Türkiye)
Countries
Review the countries where the study has at least one active or historical site.
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
2022--KAEK-37
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.