The Risk Factors Related to Rupture Flow-related Aneurysms in Posterior AVM

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-06-13

Study Completion Date

2026-12-31

Brief Summary

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AVMs have been reported to rupture at a formidable annual rate of 2% to 3% at natural progression, often resulting in longterm neurological deficits and poor functional outcomes.The reported risk of hemorrhagic presentation in patients with AVMs is 41% to 65%. While many studies suggest a correlation between higher hemorrhage risk and the concurrent presence of AVM and aneurysms, few authors have focused specifically on flow-related aneurysms alone. In many instances, the source of rupture is also unclear. Meta-analysis from 2016 suggested that 49.2% of hemorrhages were secondary to aneurysm rupture, 45% from AVM rupture, and 5.7% were undetermined.In a study of 302 patients, of which 52.6% had a hemorrhagic presentation, demonstrated a significant increase in rate of hemorrhage in those with flow-related aneurysms. Thus, it is necessary to figure out risk factors related to ruptured flow-related aneurysms in pAVM.

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Detailed Description

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Conditions

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Arteriovenous Malformation of Central Nervous System Aneurysm, Ruptured Aneurysmatic Subarachnoid Haemorrhage Aneurysm Cerebral

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Study Groups

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pAVM with ruptured flow-related aneurysm

No interventions assigned to this group

pAVM without ruptured flow-related aneurysm

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

1. pAVM with flow-related aneurysms were identified by DSA, and subarachnoid hemorrhage was confirmed by CT
2. No history of stroke, Marfan syndrome, polycystic kidney disease