miRNA Profile in Aneurysmal Subarachnoid Haemorrhage

NCT ID: NCT03344744

Last Updated: 2023-09-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-11-30

Study Completion Date

2023-08-31

Brief Summary

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The investigators aim to investigate and understand the circulating miRNA profiles after acute aneurysmal subarachnoid haemorrhage and underlying pathological significance.

Detailed Description

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1. The investigators aim to investigate the miRNA classifier for delayed cerebral infarction after aneurysmal subarachnoid haemorrhage;
2. The investigators aim to investigate the corresponding circulating and CSF miRNA profiles.

Conditions

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Subarachnoid Hemorrhage

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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SAH with DCI

Aneurysmal subarachnoid haemorrhage patients with delayed cerebral infarction

No interventions assigned to this group

SAH nonDCI

Aneurysmal subarachnoid haemorrhage patients without delayed cerebral infarction

No interventions assigned to this group

Control

Healthy volunteers

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

Aneurysmal subarachnoid hemorrhage patients within the first 72 hours or Healthy volunteers

Exclusion Criteria

Previous neurological diseases such as stroke or dementia
Minimum Eligible Age

21 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Chinese University of Hong Kong

OTHER

Sponsor Role lead

Responsible Party

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George KC Wong

Professor(Clinical)

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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George KC Wong

Role: PRINCIPAL_INVESTIGATOR

Chinese University of Hong Kong

Locations

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Department of Surgery, The Chinese University of Hong Kong

Hong Kong, , China

Site Status

Countries

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China

References

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Lu G, Wong MS, Xiong MZQ, Leung CK, Su XW, Zhou JY, Poon WS, Zheng VZY, Chan WY, Wong GKC. Circulating MicroRNAs in Delayed Cerebral Infarction After Aneurysmal Subarachnoid Hemorrhage. J Am Heart Assoc. 2017 Apr 25;6(4):e005363. doi: 10.1161/JAHA.116.005363.

Reference Type BACKGROUND
PMID: 28442458 (View on PubMed)

Su XW, Chan AH, Lu G, Lin M, Sze J, Zhou JY, Poon WS, Liu Q, Zheng VZ, Wong GK. Circulating microRNA 132-3p and 324-3p Profiles in Patients after Acute Aneurysmal Subarachnoid Hemorrhage. PLoS One. 2015 Dec 16;10(12):e0144724. doi: 10.1371/journal.pone.0144724. eCollection 2015.

Reference Type BACKGROUND
PMID: 26675167 (View on PubMed)

Wong GK, Lam S, Ngai K, Wong A, Mok V, Poon WS; Cognitive Dysfunction after Aneurysmal Subarachnoid Haemorrhage Investigators. Evaluation of cognitive impairment by the Montreal cognitive assessment in patients with aneurysmal subarachnoid haemorrhage: prevalence, risk factors and correlations with 3 month outcomes. J Neurol Neurosurg Psychiatry. 2012 Nov;83(11):1112-7. doi: 10.1136/jnnp-2012-302217. Epub 2012 Jul 31.

Reference Type BACKGROUND
PMID: 22851612 (View on PubMed)

Other Identifiers

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miSAH003

Identifier Type: -

Identifier Source: org_study_id

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