Biology of Cerebral Arteriovenous Malformations and Prognosis of Cerebral Arteriovenous Malformations

NCT ID: NCT03676868

Last Updated: 2025-06-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

300 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-11-20

Study Completion Date

2028-11-19

Brief Summary

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The cerebral arteriovenous malformations correspond to the formation of an entanglement of morphologically abnormal vessels called nidus, which shunt the blood circulation directly from the arterial circulation to the venous circulation.

The cerebral arteriovenous malformations are an important cause of hemorrhagic stroke.

The hypothesis is that cerebral haemorrhage associated with a cerebral arteriovenous malformations would come from peri-nidal micro-vessels, in connection with infiltration of leucocytes and / or defective maintenance of microvascular integrity by platelets.

Detailed Description

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Conditions

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Cerebral Arteriovenous Malformations Ruptured or Unruptured Cerebral Arteriovenous Malformations

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Patient over 18 years old
* Patient with a cerebral AVM for which an intervention (endovascular treatment or surgery) or only clinical monitoring
* Express consent to participate in the study

And

* children
* Free informed and express consent of both holders of the minor patient's parental authority, or, by way of derogation and only if the other holder of parental authority cannot give his or her consent within a time limit compatible with the methodological requirements specific to the conduct of the research with regard to its purposes, of one of the two holders of parental authority

Exclusion Criteria

* Patient benefiting from a legal protection measure
* Pregnant or breast feeding woman
Minimum Eligible Age

0 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Fondation Ophtalmologique Adolphe de Rothschild

NETWORK

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Fondation Ophtalmologique Rotschild

Paris, , France

Site Status RECRUITING

Countries

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France

Central Contacts

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Amélie Yavchitz

Role: CONTACT

01 48 63 64 54 ext. +33

Jean Philippe DESILLES

Role: CONTACT

Facility Contacts

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Dr Jean-Philippe DESILLES

Role: primary

Other Identifiers

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JDS_2018_6

Identifier Type: -

Identifier Source: org_study_id

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