AGR+PNI as Predictors of Systemic Lupus Erythematosus Disease Activity

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

140 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-08-31

Study Completion Date

2026-05-31

Brief Summary

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This study aims to evaluate the clinical utility of combining the albumin to globulin ratio (AGR) and the prognostic nutritional index (PNI) as a predictive model for assessing disease activity in patients with systemic lupus erythematosus (SLE). By correlating these nutritional and inflammatory markers with clinical manifestations and laboratory parameters, we hope to establish a simple, non-invasive, and cost-effective tool to aid in monitoring disease activity in Systemic lupus erythematosus patients.

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Detailed Description

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Conditions

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Systemic Lupus Erythematosus Disease

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Active SLE group:patients with active (SLE), fulfilling the ACR/EULAR classification criteria,

Albumin to globulin ratio and prognostic nutritional index model

Intervention Type DIAGNOSTIC_TEST

Measurement of albumin to globulin ratio and prognostic nutritional index in participants to assess disease activity in systemic lupus erythematosus patients

Healthy controls:Age and sex-matched healthy individuals without any history of autoimmune diseases

Albumin to globulin ratio and prognostic nutritional index model

Intervention Type DIAGNOSTIC_TEST

Measurement of albumin to globulin ratio and prognostic nutritional index in participants to assess disease activity in systemic lupus erythematosus patients

Interventions

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Albumin to globulin ratio and prognostic nutritional index model

Measurement of albumin to globulin ratio and prognostic nutritional index in participants to assess disease activity in systemic lupus erythematosus patients

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* · Age ≥ 18 years.

* Both sexes.
* Patients diagnosed with SLE who fulfilling the Systemic Lupus International Collaborating Clinics (SLICC) classification criteria and matched controls.

Exclusion Criteria

* Co-existing chronic inflammatory or autoimmune diseases.
* Age \<18 years
* Malignancy.
* Pregnancy or lactation.
* Chronic liver or renal insufficiency.
* Malignant hematologic diseases.
* Active hepatitis.
* Acute infection within the previous four weeks

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No