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Assessment of Hematologic Indices in Juvenile Lupus Erythematosus Patients:Correlation With Disease Activity and Chronic Organ Damage in These Patients

NCT ID: NCT06718283

Last Updated: 2024-12-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-11-30

Study Completion Date

2026-02-02

Brief Summary

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The study aim to evaluate the relationship between some important hematologic indices in juvenile lupus erythematosus patients and if these indices may be use as markers of disease acitivity in these patients or not ,also evaluate the relationship with these markers and chronic organ damage index

Detailed Description

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We calculate important hematologic indices in children diagnosed as SLE as systemic inflamatory index ,systemic inflamatory response index and aggregate index of systemic inflamation in these patients ,and correlate these indices with SLE disease activity index and chronic damage index in these patients.

Conditions

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Juvenile Systemic Lupus Erythematosus

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* patients who fillful 2012 SLICC criteria or 2019 ACR/EULAR criteria of systemic lupus erythematosus
* Age of patients at disease onset before 18 years

Exclusion Criteria

* Adult onset disease ( age at disease onset after 18 years
* Any other chronic inflamatory disorders or other autoimmune diseases
Maximum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Sohag University

OTHER

Sponsor Role lead

Responsible Party

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Alshimaa Hamdey Khalaf

Assistant lecturer- Rheumatology and Rehabilitation department

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Faculty of medicine

Sohag, , Egypt

Site Status RECRUITING

Countries

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Egypt

Central Contacts

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Alshimaa H Khalaf

Role: CONTACT

Phone: 01067790054

Email: [email protected]

Esam M Abualfadl

Role: CONTACT

Phone: 01123977966

Facility Contacts

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Alshimaa H Khalaf, Assistant lecturer

Role: primary

Esam M Abualfadl, Professor

Role: backup

References

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Aringer M, Petri M. New classification criteria for systemic lupus erythematosus. Curr Opin Rheumatol. 2020 Nov;32(6):590-596. doi: 10.1097/BOR.0000000000000740.

Reference Type BACKGROUND
PMID: 32925250 (View on PubMed)

Liu P, Li P, Peng Z, Xiang Y, Xia C, Wu J, Yang B, He Z. Predictive value of the neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, platelet-to-neutrophil ratio, and neutrophil-to-monocyte ratio in lupus nephritis. Lupus. 2020 Aug;29(9):1031-1039. doi: 10.1177/0961203320929753. Epub 2020 Jun 5.

Reference Type BACKGROUND
PMID: 32501169 (View on PubMed)

Hassan MR, Hossain A, Mahata J, Srivastava V, Sarkar S. Hematological manifestation of Pediatric Systemic Lupus Erythematosus (SLE) - A single centered cross-sectional study. J Family Med Prim Care. 2024 May;13(5):1787-1792. doi: 10.4103/jfmpc.jfmpc_1583_23. Epub 2024 May 24.

Reference Type BACKGROUND
PMID: 38948621 (View on PubMed)

Other Identifiers

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Soh-Med-24-11_3MD

Identifier Type: -

Identifier Source: org_study_id