Comparison of Interlaminar CT Guided Epidural Platelet Rich Plasma Versus Steroid Injection in Patients With Lumbar Radicular Pain

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

200 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-09-11

Study Completion Date

2028-12-31

Brief Summary

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The treatment of persistent lumbar radicular pain (LRP) using CT-guided epidural steroid injection (ESI) is widely used and associated with rare but serious complications. Platelet-rich plasma (PRP), which has recently been shown to promote healing and the anti-inflammatory process by delivering growth factors and cytokines, could be an alternative and potentially safer option. A previous study showed that PRP was as effective as ESI in treating this condition, without major complications.

This study aims to compare these two treatments over the long term (2 years).

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Detailed Description

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Conditions

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Herniated Disc

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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steroid treatment

Group Type ACTIVE_COMPARATOR

Epidural Steroid Injection

Intervention Type PROCEDURE

Intervention consists of interlaminar CT guided epidural steroid injection

platelet-rich plasma treatment

Group Type EXPERIMENTAL

Epidural platelet-rich plasma injection

Intervention Type PROCEDURE

Intervention consists of interlaminar CT guided epidural platelet-rich plasma injection after recovery of plasma by blood sampling and centrifugation

Interventions

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Epidural Steroid Injection

Intervention consists of interlaminar CT guided epidural steroid injection

Intervention Type PROCEDURE

Epidural platelet-rich plasma injection

Intervention consists of interlaminar CT guided epidural platelet-rich plasma injection after recovery of plasma by blood sampling and centrifugation

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Diagnosis of unilateral resistant LRP associated with a herniated disc on MRI images. (Diagnosis of resistance after 6 weeks of appropriate medical treatment).

Exclusion Criteria

* Patients with infections,
* Patients who have had previous percutaneous corticosteroid injections,
* Patients undergoing systemic corticosteroid treatment,
* Patients with immune deficiencies,
* Patients who are allergic to the contrast medium used,
* Pregnant or breastfeeding patients,
* Patients with a history of allergies to anesthetics or corticosteroids,
* Anticoagulant treatment or blood disorders, patients on antiplatelet therapy
* Taking NSAIDs within two weeks prior to the procedure

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No