Impact of Pre- and Post-operative Serum Metabolome Dynamics in Colorectal Resection Outcomes

NCT ID: NCT07035262

Last Updated: 2025-06-25

Basic Information

• Recruitment Status: ACTIVE_NOT_RECRUITING
• Total Enrollment: 400 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2023-01-01
• Study Completion Date: 2025-09-01

Brief Summary

The aim of this study is to systematically analyze the dynamic pattern of preoperative and postoperative serum metabolites in colorectal cancer patients through metabolomics technology, and to screen the key metabolites with statistical differences and explore their correlation with surgical interventions by combining the baseline characteristics of the patients with the perioperative clinical data; to further reveal the impact of surgery on the body's metabolic remodeling pattern, and to explore the potential biomarkers and regulatory pathways, providing a theoretical basis for elucidating the metabolic mechanism. Investigaters will further reveal the impact of surgery on metabolic remodeling, explore potential biomarkers and regulatory pathways, provide theoretical basis for elucidating the metabolic mechanism, and evaluate its clinical translational value (e.g., postoperative monitoring, targeted intervention, etc.), so as to lay the foundation for the subsequent basic research and precise treatment strategies.

Conditions

Colo-rectal Cancer

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Study Groups

the colorectal cancer group

patients diagnosed with colorectal cancer

serum metabolites

Intervention Type: OTHER

serum metabolites before and after colorectal cancer surgery

Interventions

serum metabolites

serum metabolites before and after colorectal cancer surgery

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Previous consent to participate;
• Blood drawn and serum samples extracted and preserved both preoperatively and postoperatively;
• Successful detection of metabolomics profiles from serum samples;
• Acceptance of a standard radical colorectal cancer procedure;
• Complete perioperative data available;
• Adults with a pathologic diagnosis of colorectal cancer

Exclusion Criteria

• Have or have had a previous history of other malignancies;
• Have a history of radiotherapy treatment;
• Have a history of inflammatory bowel disease;
• Have a familial history of genetic disorders;
• Missing baseline data (age, BMI, gender, previous medical history, etc.);
• Failed to leave the hospital earlier than medically indicated;
• Failed to sign an informed consent form.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Dong Peng

OTHER

Sponsor Role: lead

Responsible Party

Dong Peng

Principal Investigator

Responsibility Role: SPONSOR_INVESTIGATOR

Locations

The First Affiliated Hospital of Chongqing Medical University

Chongqing, Chongqing Municipality, China

Countries

China

Other Identifiers

2025-364-01

Identifier Type: -

Identifier Source: org_study_id