Psoas Density in Colorectal Cancer

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

1000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-01-01

Study Completion Date

2020-12-01

Brief Summary

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Colorectal cancer (CRC) is the 3rd most common cancer worldwide. In the UK, CRC is the 4th most common cancer accounting for 12% of cancers diagnosed each year with approximately 41,300 new cases diagnosed in 2014. Surgery remains the only treatment option that can reliably achieve cure from colorectal cancer and thus nearly 20,000 major bowel resections are performed for this yearly in the UK. Surgery for these cancers however carries risk of major complications and potentially death. Selecting appropriate patients for surgery remains a challenge to cancer teams.

Risk factors exist for complications after surgery for CRC, many of which can be assessed and discussed with the patient prior to surgery, so that any decision to operate is with fully informed consent from the patient. Increasing attention is being paid to a patient's frailty or fitness as one of these risk factors. Our centre has previously shown that measuring the cross-sectional area of the psoas muscle (a large muscle near the spine) from preoperative imaging could predict major complications in colorectal cancer patients (Jones 2015), however specialist software and patient height is required to make this calculation. More recently we have demonstrated that the measurement of the psoas muscle density on preoperative imaging (i.e. routine CT scans that all patients have before surgery to plan treatment), may potentially be useful to predict which patients are at most risk of a major complication (Herrod 2019). If this finding holds true when tested on a larger scale, it could be used to help surgical teams make the decision on whether to offer surgical resection, what kind of operations to perform, how to best support individuals undergoing operation and to ensure that the patient has the most information available to decide what risk they are at by having major surgery.

Detailed Description

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Conditions

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Cancer of Colon

Keywords

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psoas muscle density frailty

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Patients who underwent colorectal resection

Patients in this observational study will have undergone CT scan as routine work up prior to resection of elective colorectal cancer.

Psoas muscle density will be measured (in Hounsfield units from CT images) at lumbar vertebral level L3.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

Patient criteria:

* Having a major colorectal resection for the treatment of cancer
* Elective or emergency surgery
* Adults, defined as age ≥18 years of age (no maximum limit)
* Had a preoperative CT scan of the abdomen with contrast (portal venous phase)
* Operation performed between 31st Aug 2013 - 31st Aug 2019

Exclusion Criteria

* Not having a preoperative CT scan with contrast

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

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Responsibility Role SPONSOR

Locations

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School of Graduate Entry Medicine, Royal Derby Hospital

Derby, Derbyshire, United Kingdom

Site Status

Countries

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United Kingdom

Central Contacts

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Jonathan N Lund, MD

Role: CONTACT

Phone: 01332 340131

Email: [email protected]

James EM Blackwell, PhD BMBS