Precision Medicine for Colorectal Cancer Liver Metastasis Guided by Multi-omics Data Under the Umbrella Theory
NCT ID: NCT04525807
Last Updated: 2020-08-25
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
200 participants
OBSERVATIONAL
2020-09-01
2022-09-01
Brief Summary
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Therefore, based on the umbrella theory of precision medicine, we carried out this single-center, prospective, and observational study to include patients with liver metastases from colorectal cancer. By combining genome, transcriptome, and proteomic sequencing data, we established a basis for colorectal cancer liver Transfer the multi-omics data of the sample, describe the reason for the resistance of the first-line treatment, and search for new therapeutic targets.
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Multiomics arm
Guide therapy based on multi-omics
Multi-omics
Use multi-omics to analyze
Interventions
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Multi-omics
Use multi-omics to analyze
Eligibility Criteria
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Inclusion Criteria
* Pathologically diagnosed patients with colorectal cancer
* Combined with liver metastases confirmed by imaging, and the lesion is measurable (RECIST standard)
* The lesion is available
* First-line treatment failed; hematology, liver and kidney function tests are suitable for back-line treatment
* Informed consent
Exclusion Criteria
* History of other malignancies
* Pregnancy or breastfeeding
* Have received other drug clinical studies within 30 days before the start of this study
18 Years
70 Years
ALL
No
Sponsors
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Fudan University
OTHER
Responsible Party
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Other Identifiers
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2020-08
Identifier Type: -
Identifier Source: org_study_id
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