Impact of Surgical Management for Relapse After Conversion Hepatectomy for Initially Unresectable Colorectal Liver Metastasis

NCT ID: NCT05462470

Last Updated: 2022-07-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

255 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-01-01

Study Completion Date

2022-04-30

Brief Summary

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For patients with initially unresectable colorectal liver metastasis (IU-CRLM) receiving effective conversion therapy, disease relapse after conversion hepatectomy is common due to the extensive tumor load. Yet, few studies have focused on the assessment and management of relapse after conversion hepatectomy for IU-CRLM. This study aimed to investigate the impact of surgical management for relapse after conversion hepatectomy in IU-CRLM.

Detailed Description

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Conditions

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Colorectal Cancer Liver Metastases

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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repeat liver surgery

repeat liver surgery for liver relapse lesions

Repeat Liver Surgery

Intervention Type PROCEDURE

repeat liver surgery included not only hepatectomy, but also ablative treatment, including radiofrequency ablation (RFA) and microwave ablation (MWA)

non-repeat liver surgery

non-repeat liver surgery, just only systemic palliative chemotherapy

Non-Repeat Liver Surgery

Intervention Type PROCEDURE

Systemic palliative chemotherapy

Interventions

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Repeat Liver Surgery

repeat liver surgery included not only hepatectomy, but also ablative treatment, including radiofrequency ablation (RFA) and microwave ablation (MWA)

Intervention Type PROCEDURE

Non-Repeat Liver Surgery

Systemic palliative chemotherapy

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* initially unresectable colorectal liver metastasis (IU-CRLM)
* received conversion therapy
* underwent conversion hepatectomy

Exclusion Criteria

* the histologic type of CRLM was not called adenocarcinoma
* uncontrollable extrahepatic metastases, such as peritoneal, bone, brain metastasis
* history of previous hepatectomy
* the primary tumor was not resected or palliative resection
* R1 or R2 liver resection
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Fudan University

OTHER

Sponsor Role lead

Responsible Party

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Xu jianmin

Deputy director of the department of general surgery

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jianmin Xu, MD

Role: PRINCIPAL_INVESTIGATOR

Department of General Surgery, Zhongshan Hospital, Fudan University

Other Identifiers

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IU-CRLM

Identifier Type: -

Identifier Source: org_study_id

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