Multiple Minor Hepatectomies Versus Major or Extended Hepatectomies for Colorectal Liver Metastases.

NCT ID: NCT02331641

Last Updated: 2015-01-06

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 554 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2005-01-31
• Study Completion Date: 2014-12-31

Brief Summary

The performance of multiple minor hepatectomies (MMH) instead of major hepatectomies (MH) in patients with colorectal liver metastases (CLM) is object of debate. We build a study, using the propensity score matched analysis, to compare the short- and long-term outcome of the tow groups of patients.

Detailed Description

The aim of this study is to investigate the outcome of patients with colorectal liver metastases (CLM) undergoing multiple minor hepatectomies (MMH) instead of major hepatectomies (MH). Indeed, the performance of MMH versus MH in patients with CLM is object of debate. For this purpose, the databases at two independent institutions were retrospectively reviewed. To control for confounding variable distributions, a propensity score-matched analysis 1:1 was performed, and the nearest neighbor-matching method with caliper distance of 0.01 was used. Among 554 patients, 110 patients undergoing MMH and 110 undergoing MH were matched. They were similar in baseline characteristics, comorbidities, features of the primary tumors, and CLM. Primary outcomes were short- and long-term outcome.

Conditions

Colorectal Liver Metastases; Colon Cancer

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: RETROSPECTIVE

Study Groups

Major hepatectomy (MH)

Patients who underwent MH for CLM instead of multiple minor hepatectomy (MMH)

Hepatectomy

Intervention Type: PROCEDURE

Removal of a part of the liver

Multiple minor hepatectomy (MMH)

Patients who underwent MMH for CLM instead of MH

Hepatectomy

Intervention Type: PROCEDURE

Removal of a part of the liver

Interventions

Hepatectomy

Removal of a part of the liver

Intervention Type: PROCEDURE

Other Intervention Names

Hepatic resection

Eligibility Criteria

Inclusion Criteria

• Diagnosis of CLM

Exclusion Criteria

• Uncertain diagnosis
• Lost at follow-up

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

University of Bologna

OTHER

Sponsor Role: collaborator

University of Milan

OTHER

Sponsor Role: lead

Responsible Party

Prof. Guido Torzilli

Professor of Surgery

Responsibility Role: PRINCIPAL_INVESTIGATOR

Other Identifiers

MajorVsMinorHepatectomy

Identifier Type: -

Identifier Source: org_study_id