Multidisciplinary Management of HCC in Elderly Patients
NCT ID: NCT03875417
Last Updated: 2019-03-14
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
126 participants
OBSERVATIONAL
2018-01-01
2018-10-31
Brief Summary
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Detailed Description
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Materials and methods- 126 patients, aged between 65 and 90 years, submitted to liver resection for HCC were enrolled. They were divided into three classes. Class 1 included patients submitted to major resections, Class 2 to minor resections and Class 3 to minor resections associated with thermoablation. All of them were clinically and radiologically followed up. Patients who developed recurrences (Group A) were referred to further treatments (surgery, interventional radiology or pharmacological therapy). Mortality, disease-free survival (DFS), overall survival (OS) and quality of life (QoL) were evaluated and compared with non-recurrent patients (Group B).
Used interventional radiology means were Radiofrequency ablation (RF), microwaves ablation (MWA) or transcatheter arterial chemoembolization (TACE).
Conditions
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Study Design
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CASE_CONTROL
RETROSPECTIVE
Study Groups
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Group A
Patients who developed HCC recurrences after surgery and treated with re-resection, or microinvasive non-surgical means.
liver resection
resection of one or more HCC nodules within the liver
Thermic ablation
ablation of HCC nodule through a percutaneous needle, by using radiofrequency or microwaves
Transcatheter arterial chemoembolization
embolization of HCC nodule via drug-eluted microbeads.
Group B
Patients who did not develop recurrences after surgery.
liver resection
resection of one or more HCC nodules within the liver
Interventions
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liver resection
resection of one or more HCC nodules within the liver
Thermic ablation
ablation of HCC nodule through a percutaneous needle, by using radiofrequency or microwaves
Transcatheter arterial chemoembolization
embolization of HCC nodule via drug-eluted microbeads.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* eligible for surgery
Exclusion Criteria
65 Years
ALL
No
Sponsors
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Azienda Policlinico Umberto I
OTHER
Responsible Party
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Professor Stefania Brozzetti
Associate Professor
Principal Investigators
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Stefania Brozzetti, Professor
Role: PRINCIPAL_INVESTIGATOR
Policlinico Umberto I - Sapienza università di Roma
Locations
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Department of Surgery "Pietro Valdoni"
Roma, , Italy
Countries
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Other Identifiers
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HEP001
Identifier Type: -
Identifier Source: org_study_id
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