Microwave Ablation Combined With Chemotherapy for Colorectal Liver Metastases： a Multicenter Cohort Study

NCT ID: NCT04562727

Last Updated: 2021-03-04

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Clinical Phase: NA
• Total Enrollment: 668 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2021-03-01
• Study Completion Date: 2026-09-01

Brief Summary

Colorectal cancer is the second deadliest malignant tumor worldwide, and liver is the most common site of hematogenic metastasis of Colorectal cancer. Surgery is an effective treatment for colorectal cancer with liver metastasis, however, only 10%-20% of patients with liver metastasis are feasible for radical surgical resection. Many single-center retrospective studies have demonstrated that thermal ablation for liver metastases is comparable to surgery. Chemotherapy can kill the microscopic cancer foci of the liver. The timing of ablation-related chemotherapeutic administration still needs to be explained.

The purpose of this study was to compare the clinical efficacy of thermal ablation or combined with perioperative chemotherapy and postoperative chemotherapy in the treatment of colorectal cancer with liver metastasis.

Detailed Description

Colorectal cancer is the second deadliest malignant tumor worldwide, and liver is the most common site of hematogenic metastasis of Colorectal cancer. Surgery is an effective treatment for colorectal cancer with liver metastasis, however, only 10%-20% of patients with liver metastasis are feasible for radical surgical resection.

In the early 1990s, radiofrequency ablation (RFA) was first applied in the treatment of liver metastases. In the late 1990s and early 2000s, microwave ablation (MWA), irreversible electroporation (IRE) and other technologies emerged. Today, with the continuous improvement of ablation techniques, many single-center retrospective studies have demonstrated that thermal ablation for liver metastases is comparable to surgery. Currently, institutions have conducted multi-center randomized controlled trials to compare the outcomes of the two treatment approaches. The expert consensus of tumor ablation therapy has confirmed that the ablation technique has the advantages of minimally invasive, well tolerated and low complications, and has been widely used in the treatment of solid tumors. In the treatment of liver metastases, it also has the advantage of not being limited by residual liver volume.

Postoperative tumor recurrence occurred in about 2/3 of the patients with liver stump, mainly due to the residual microscopic cancer foci. Chemotherapy can kill the microscopic cancer foci of the liver. EORTC (40983) confirmed that: compared with surgery alone, perioperative chemotherapy for resectable liver metastases (<4) could benefit patients with PFS and reduce the incidence of tumor progression-related events. EORTC (40004) proved that in the treatment of non-resectable liver metastases (1 ~ 10, with a maximum diameter <4cm), ablation combined with postoperative chemotherapy was superior to chemotherapy alone. E. Tanis et al compared two randomized controlled trials of EORTC for colorectal cancer liver metastasis, namely 40983 (EPOC) and 40004 (CLOCC), and confirmed the treatment of liver metastasis (<3cm) after integration. There was no significant difference in local recurrence rate between the RFA+ postoperative chemotherapy group and the surgery + perioperative chemotherapy group. At the beginning, neoadjuvant chemotherapy was designed to provide surgical resection opportunities for patients who could not be resected with metastatic tumor. Later, it was gradually applied to resectable liver metastasis. Studies on surgical combination with chemotherapy proved that preoperative chemotherapy was no less effective than postoperative chemotherapy for resectable liver metastasis. However, for isolated small metastatic tumors (<3cm), complete tumor response after neoadjuvant chemotherapy should be avoided, leading to the dilemma of inoperable. Studies have reported that ablation combined with preoperative chemotherapy can cause hepatic steatosis and tumor shrinkage, which makes tumor visualization difficult to a certain extent. If the tumor disappeared on imaging, the pathological specimen confirmed that there were still residues, and the tumor could "reappear" during follow-up. Therefore, the timing of ablation-related chemotherapeutic administration still needs to be explained, and there is still a lack of high-quality evidence-based medical evidence at home and abroad.

The purpose of this study was to compare the clinical efficacy of thermal ablation or combined with perioperative chemotherapy and postoperative chemotherapy in the treatment of colon cancer with liver metastasis.

Conditions

Colorectal Carcinoma; Chemotherapy; Liver Metastases

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: QUADRUPLE

Study Groups

Only MWA

Only preform MWA, chemotherapy isn't necessary

Group Type: EXPERIMENTAL

Chemotherapy

Intervention Type: DRUG

perioperative chemotherapy or postoperative chemotherapy

MWA combined with perioperative chemotherapy

MWA combined with perioperative chemotherapy. Chemotherapy was preformed before MWA and after MWA

Group Type: ACTIVE_COMPARATOR

Chemotherapy

Intervention Type: DRUG

perioperative chemotherapy or postoperative chemotherapy

MWA combined with postoperative chemotherapy

MWA combined with perioperative chemotherapy. Chemotherapy was preformed after MWA

Group Type: EXPERIMENTAL

Chemotherapy

Intervention Type: DRUG

perioperative chemotherapy or postoperative chemotherapy

Interventions

Chemotherapy

perioperative chemotherapy or postoperative chemotherapy

Intervention Type: DRUG

Other Intervention Names

preoperative chemotherapy; postoperative chemotherapy

Eligibility Criteria

Inclusion Criteria

• 1) Aged between 18 and 80, WHO physical status score < level 2
• 2) Histologically confirmed colorectal cancer, liver metastasis (≤4), maximum diameter ≤4cm;
• 3) Patients without extrahepatic metastasis;
• 4) If the primary tumor has been resected or has metastasized at the same time, the multidisciplinary panel determines that the primary tumor can be resected and resected within one month after ablation;
• 5) No other chemotherapy experience except anti-tumor treatment for the primary cancer;
• 6) The main organs function normally, that is, they meet the following standards:

1. Blood routine examination: HB≥90 g/L; The ANC acuity 1.5 x 109 / L; PLT 60 x 109 / L or higher;

2. Biochemical examination: ALB ≥29g/L; ALT and AST < 3 uln; 1.5 ULN TBIL or less; Creatinine 1.5 or less ULN.

Exclusion Criteria

• 1) A history of other malignant tumors in the past 5 years;
• 2) Cardiovascular diseases with significant clinical symptoms (uncontrolled congestive heart failure, angina pectoris, hypertension, arrhythmia);
• 3) Persons with coagulation disorders;
• 4) Combined with active infection;
• 5) Those with any contraindications related to chemotherapy;
• 6) Pregnant or lactating women;
• 7) A history of substance abuse and mental illness;
• 8) The investigator believes that there are any other factors that are not suitable for inclusion or affect the subject's participation in the study.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Ping Liang

OTHER

Sponsor Role: lead

Responsible Party

Ping Liang

Interventional ultrasound department

Responsibility Role: SPONSOR_INVESTIGATOR

Principal Investigators

Ping Liang, Doctor

Role: PRINCIPAL_INVESTIGATOR

Chinese PLA General Hospital

Central Contacts

jianming Li, Dr

Role: CONTACT

lijianming@ccmu.edu.cn

860118810611944

Ping Liang, Doctor

Role: CONTACT

References

Li J, Pang C, Liu G, Xie X, Zhang DZ, Li K, Li Z, He G, Xu E, Zhong H, Yang H, Lu M, Lou K, Xie X, Lan S, Li Q, Dai G, Yu J, Liang P. Thermal ablation with and without adjuvant systemic therapy: a nationwide multicenter observational cohort study of solitary colorectal liver metastases. Int J Surg. 2024 Jul 1;110(7):4240-4248. doi: 10.1097/JS9.0000000000001397.

Reference Type: DERIVED

PMID: 38597399 (View on PubMed)

Other Identifiers

S2020-266-01

Identifier Type: -

Identifier Source: org_study_id