The Outcomes of Laparoscopic Hybrid Surgery Versus Totally Open Surgery

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

266 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-01-01

Study Completion Date

2024-08-01

Brief Summary

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Simultaneous colorectal cancer liver metastasis (SCRLM) is one of the risk factors for poor prognosis in colorectal cancer. Surgical resection of primary and metastatic lesions is the first choice of treatment for patients with resectable SCRLM. Simultaneous resection of colorectal cancer liver metastases by totally open surgery (TOS) has been widely used. However, we propose that laparoscopic hybrid surgery (LHS) may have better short and long-term outcomes. This study aimed to compare the safety, short-term, and long-term efficacy of LHS versus TOS for patients with resectable SCRLMs.

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Detailed Description

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Conditions

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Resectable Simultaneous Colorectal Cancer Liver Metastasis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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laparoscopic hybrid surgery (LHS) cohort

Routine colorectal surgery is performed first, followed by liver surgery. The LHS cohort first performed the laparoscopic exploration of the entire abdominal-pelvic cavity to determine the resectability of the primary and metastatic lesions. After the blood vessel detachment and bowel detachment, the distal bowel of the tumor was severed and the pneumoperitoneum was closed. The liver metastases were then removed in both cohorts by open resection through the right subcostal incision.

laparoscopic hybrid surgery (LHS)

Intervention Type PROCEDURE

First performed the laparoscopic exploration of the entire abdominal-pelvic cavity to determine the resectability of the primary and metastatic lesions. After the blood vessel detachment and bowel detachment, the distal bowel of the tumor was severed and the pneumoperitoneum was closed. The liver metastases were then removed in both cohorts by open resection through the right subcostal incision.

totally open surgery (TOS) cohort

Routine colorectal surgery is performed first, followed by liver surgery. The blood vessel detachment, bowel detachment, the distal bowel of the tumor in the TOS cohort were accomplished by open surgery through the mid-abdominal incision approach. The liver metastases were then removed in both cohorts by open resection through the right subcostal incision.

No interventions assigned to this group

Interventions

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laparoscopic hybrid surgery (LHS)

First performed the laparoscopic exploration of the entire abdominal-pelvic cavity to determine the resectability of the primary and metastatic lesions. After the blood vessel detachment and bowel detachment, the distal bowel of the tumor was severed and the pneumoperitoneum was closed. The liver metastases were then removed in both cohorts by open resection through the right subcostal incision.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Liver metastasis was detected while the colorectal cancer was diagnosed.
* Both the primary lesions and liver metastases were confirmed by postoperative pathological examination.
* Clinical data is complete.

Exclusion Criteria

* Patients with unresectable extrahepatic metastases.
* Patients with other malignant tumor diseases that have not been cured.
* Clinical and pathological data were missed or incomplete follow-up data.

Eligible Sex

ALL

Accepts Healthy Volunteers

No