Measuring Molecular Residual Disease in Colorectal Cancer After Primary Surgery and Resection of Metastases

NCT ID: NCT03189576

Last Updated: 2023-05-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

37 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-10-01

Study Completion Date

2023-08-30

Brief Summary

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Circulating tumour DNA (ctDNA) is a promising tool when monitoring the residual disease in colorectal cancer (CRC). Current staging procedures are insufficient to identify the patient cohort at high risk, who might benefit from additional adjuvant therapy.

We will show that the assessment of ctDNA is a non-invasive approach and easily taken at different time points via simple blood draw to monitor residual disease from the colorectal cancer patients after primary surgery. Minimal residual disease could be used in the future for individualized treatment decisions after primary surgery.

Detailed Description

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Conditions

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Colorectal Cancer Residual Disease

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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CRC patients after primary surgery

sequential blood draw taken to monitor residual disease

Group Type OTHER

blood draw

Intervention Type DIAGNOSTIC_TEST

Interventions

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blood draw

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* planned colorectal primary surgery

Exclusion Criteria

* unfit patients with dementia
Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Tampere University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Pirkko-Liisa Kellokumpu-Lehtinen

professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Pirkko-Liisa Kellokumpu-Lehtinen, professor

Role: STUDY_DIRECTOR

Tampere University Hospital

Locations

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Tampere University Hospital

Tampere, , Finland

Site Status

Countries

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Finland

Other Identifiers

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ETL R15085

Identifier Type: -

Identifier Source: org_study_id

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