The Effect of Platelet Rich Fibrin Layers on Peri-implant Tissue Phenotype
NCT ID: NCT07033351
Last Updated: 2025-06-27
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
31 participants
INTERVENTIONAL
2025-02-01
2025-06-06
Brief Summary
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Central to the study are two specific inquiries: Does the application of PRF correlate with an increase in the width and thickness of keratinized mucosa surrounding the implant? Is there a dose-response relationship such that the use of multiple PRF layers yields superior maintenance of bone height compared with a single layer or no PRF at all?
To address these questions, clinicians will juxtapose three treatment groups: one receiving no PRF, another receiving a single membrane, and a third receiving a triple-layer graft. Healing parameters will be measured before surgery and again at 6-week and 12-week checkpoints, allowing direct appraisal of outcome changes across the comparative cohorts.
Each participant will ultimately be allotted to one of the experimental arms by random assignment, thus mitigating selection bias. Routine follow-up examinations and radiographic imaging, will be used to track healing progress.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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0 PRF
Each implant placed in this group did NOT have PRF membrane placed over the implant.
Dental implant placement without PRF
Standard dental implant placement procedure with flap elevation and suturing, without the application of any PRF membrane over the implant site.
1 PRF
Each implant placed in this group had ONE PRF membrane placed over the implant.
Single-layer PRF membrane application
PRF membrane prepared via centrifugation is applied as a single layer over the implant site following implant placement before flap closure.
3 PRF
Each implant placed in this group had THTEE STACKED PRF membranes placed over the implant.
Triple-layer PRF membrane application
Three autologous PRF membranes prepared via centrifugation are stacked and applied as a 3-layer membrane over the implant site before flap closure.
Interventions
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Dental implant placement without PRF
Standard dental implant placement procedure with flap elevation and suturing, without the application of any PRF membrane over the implant site.
Single-layer PRF membrane application
PRF membrane prepared via centrifugation is applied as a single layer over the implant site following implant placement before flap closure.
Triple-layer PRF membrane application
Three autologous PRF membranes prepared via centrifugation are stacked and applied as a 3-layer membrane over the implant site before flap closure.
Eligibility Criteria
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Inclusion Criteria
* Partially edentulous spaces.
* No history of bone augmentation procedures in the implant site.
* Good oral health, as measured by:
* Calibrated gingival bleeding index (≤10%)
* O'Leary plaque index (\<10%)
Exclusion Criteria
* Compromised immune systems.
* Excessive smoking or alcohol consumption.
* Poor oral hygiene.
* Diabetes.
* Inability to attend follow-up visits.
18 Years
75 Years
ALL
Yes
Sponsors
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Al-Mustansiriyah University
OTHER
Responsible Party
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Ahmed Mahir Tawfeeq Karakchi
Principal Investigator
Locations
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University of Mosul / College of Dentistry
Mosul, Nenavah, Iraq
Countries
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Other Identifiers
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MUOSU-202131
Identifier Type: -
Identifier Source: org_study_id
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