Temporal Interference for Essential Tremor

NCT ID: NCT07016425

Last Updated: 2025-07-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-06-09

Study Completion Date

2026-09-30

Brief Summary

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This single-center prospective study aims to investigate the treatment efficacy of temporal interference (TI) in essential tremor patients aged 30-70.

Detailed Description

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Temporal Interference (TI) technology is a novel non-invasive method for deep brain stimulation (DBS). By generating an overlapping electric field from safe currents, TI creates focused stimulation in targeted deep brain areas. This approach allows for the exploration of deep brain nuclei functions and has the potential to serve as a non-invasive alternative to traditional invasive DBS for clinical treatments.

This study aims to investigate the treatment efficacy of TI deep brain stimulation by including essential tremor patients aged 30-70. Before and after TI stimulation, clinical data will be recorded. Clinical and imaging data will be analyzed and processed to advance the treatment of essential tremor.

Conditions

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Essential Tremor

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Temporal Interference

The investigators perform temporal interference (TI) stimulation to patients with essential tremor. They observe clinical manifestations before and after stimulation to investigate the efficiency of TI.

Group Type EXPERIMENTAL

Temporal Interference

Intervention Type OTHER

Researchers apply temporal interference (TI) stimulation to the deep brain nuclei of essential tremor patients.

Interventions

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Temporal Interference

Researchers apply temporal interference (TI) stimulation to the deep brain nuclei of essential tremor patients.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Aged 30-70 years old, regardless of gender. Action tremor and postural tremor in both upper limbs, or action tremor and postural tremor in one limb;
* No history of mental diseases;
* Informed consent signed.

Exclusion Criteria

* Presence of other neurological diseases affecting the study (such as epilepsy);
* Patients with moderate to severe cognitive impairment (Montreal Cognitive Assessment ≤ 18 points);
* Orthopedic diseases that may affect motor symptoms;
* Patients taking antipsychotic or antidepressant medications;
* Presence of metal implants in the body (such as brain pacemakers or cardiac pacemakers);
* History of electroconvulsive therapy;
* Presence of cardiovascular risk factors, etc.
Minimum Eligible Age

30 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Liankun_Ren

OTHER

Sponsor Role lead

Responsible Party

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Liankun_Ren

Professor

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Liankun Ren, MD

Role: PRINCIPAL_INVESTIGATOR

Xuanwu Hospital, Beijing

Locations

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Xuanwu Hospital, Capital Medical University

Beijing, Beijing Municipality, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Liankun Ren, MD

Role: CONTACT

+86 13681576621

Facility Contacts

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Liankun Ren, MD

Role: primary

+86 13681576621

Other Identifiers

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2024-426-002

Identifier Type: -

Identifier Source: org_study_id

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