Morphine and Dexmedetomidine as Adjuvants to Bupivacaine in Ultrasound-guided Erector Spinae Plane Block for Open Subcostal Renal Surgeries
NCT ID: NCT07012590
Last Updated: 2025-06-10
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
147 participants
INTERVENTIONAL
2023-05-01
2024-07-31
Brief Summary
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Detailed Description
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The erector spinae plane block (ESPB) is a novel interfascial plane technique, aiming to block the dorsal and ventral rami of the spinal nerves to provide visceral and somatic multi-dermatomal analgesia of the cervical, thoracic, and lumbar levels.
Adjuvants to local anesthetics, such as morphine and dexmedetomidine, can be used to improve the quality and duration of peripheral nerve block effects.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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Morphine group
Patients received erector spinae plane block with morphine 2 mg as an adjuvant to bupivacaine 30 ml 0.25%.
Morphine
Patients received erector spinae plane block with morphine 2 mg as an adjuvant to bupivacaine 30 ml 0.25%.
Dexmedetomidine group
Patients received erector spinae plane block with dexmedetomidine 100 µg as an adjuvant to bupivacaine 30 ml 0.25%.
Dexmedetomidine
Patients received erector spinae plane block with dexmedetomidine 100 µg as an adjuvant to bupivacaine 30 ml 0.25%.
Control group
Patients received erector spinae plane block with bupivacaine 30 ml 0.25% only.
Erector spinae plane block
Patients received erector spinae plane block with bupivacaine 30 ml 0.25% only.
Interventions
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Morphine
Patients received erector spinae plane block with morphine 2 mg as an adjuvant to bupivacaine 30 ml 0.25%.
Dexmedetomidine
Patients received erector spinae plane block with dexmedetomidine 100 µg as an adjuvant to bupivacaine 30 ml 0.25%.
Erector spinae plane block
Patients received erector spinae plane block with bupivacaine 30 ml 0.25% only.
Eligibility Criteria
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Inclusion Criteria
* Age: 20 - 65 years.
* Physical Status: American Society of Anesthesiologists (ASA) I \& II.
* Patients undergoing open subcostal renal surgeries.
Exclusion Criteria
* Age: \>65 and \<20 years.
* Allergy to Dexmedetomidine, local anesthetics, systemic opioids, and any of the drugs included in the multimodal perioperative pain protocol.
* Patient with coagulation disorders.
* Chronic pain syndromes and patients with chronic opioid use are defined as use of regular daily doses of systemic narcotics for the past 6 months before the surgery.
* Body mass index of 35 kg/ m2 or more.
* Physical Status: American Society of Anesthesiologists (ASA) III \& IV.
* Local infection or sepsis at the site of injection.
20 Years
65 Years
ALL
No
Sponsors
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Kafrelsheikh University
OTHER
Responsible Party
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Ayman Essam Kaka
Resident of Anesthesia, Surgical Intensive Care and Pain Management, Faculty of Medicine, Kafr Elsheikh University, Kafr Elsheikh, Egypt.
Locations
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Kafrelsheikh University
Kafr ash Shaykh, Kafrelsheikh, Egypt
Countries
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Other Identifiers
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KFSIRB200-525
Identifier Type: -
Identifier Source: org_study_id
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