Postoperative Analgesic Effects of Dexmedetomidine for Transversus Abdominis Plane Block

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

90 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-02-28

Study Completion Date

2015-09-30

Brief Summary

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the aim of this study is evaluate postoperative analgesic effects of dexmedetomidine added to bupivacaine on TAP block in patients undergoing lower abdominal surgery.

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Detailed Description

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TAP block is being used a method of multimodal balanced analgesia reduces postoperative pain, opioid requirement after surgery and adverse effect of opioid such as sedation, nausea vomiting and ileus. Dexmedetomidine ,an alfa-2 adrenoreceptor agonist, is being used and adjuvant capable of prolonging duration of sensory and motor block on nerve blocks.

Conditions

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Pain

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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bupivacaine

0,5% 20 ml bupivacaine added 0.9% 1 ml serum physiologic on TAP block

Group Type ACTIVE_COMPARATOR

Bupivacaine

Intervention Type DRUG

21 ml 0.5 %bupivacaine is applied interfasially

dexmedetomidine

100 mcg dexmedetomidine added to 0,5% 20 ml bupivacaine on TAP block

Group Type ACTIVE_COMPARATOR

Dexmedetomidine

Intervention Type DRUG

1 ml dexmedetomidin + 20 ml 0.5 % bupivacaine are applied interfasially

serum phsyologic

0,9% 21 ml serum physiologic

Group Type SHAM_COMPARATOR

serum physiologic

Intervention Type DRUG

21 ml serum physiologic is applied interfasially

Interventions

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Bupivacaine

21 ml 0.5 %bupivacaine is applied interfasially

Intervention Type DRUG

Dexmedetomidine

1 ml dexmedetomidin + 20 ml 0.5 % bupivacaine are applied interfasially

Intervention Type DRUG

serum physiologic

21 ml serum physiologic is applied interfasially

Intervention Type DRUG

Other Intervention Names

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marcaine precedex

Eligibility Criteria

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Inclusion Criteria

* ASA 1-2
* 18-65 aged
* patient undergoing lower abdominal surgery

Exclusion Criteria

* chronic opioid consumption
* bupivacaine and dexmedetomidine allergies
* coagulopathy
* infection at the needle insertion side
* chronic liver and kidney disease

Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No