Does Vitamin C Improve Postoperative Healing

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

56 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-06-01

Study Completion Date

2025-03-01

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This randomized, split-mouth clinical trial investigates the effect of oral vitamin C supplementation on postoperative recovery following the surgical extraction of impacted mandibular third molars. Fifty-six healthy patients underwent bilateral extractions, with each side randomly assigned to receive either 1000 mg of oral vitamin C or a placebo. The supplementation began one day before surgery and continued through postoperative day 7. The outcome measures included facial swelling assessed through linear measurements (tragus-pogonion, tragus-commissure labiorum, and lateral canthus of the eye-angulus mandible), pain using a visual analog scale (VAS), trismus based on maximum interincisal opening, and early wound healing assessed with the Landry healing index. Analgesic consumption was also recorded. Pain was evaluated using VAS on days 1, 2, and 7. Edema, trismus, and early wound healing were evaluated on postoperative days 2 and 7. The study aims to determine whether vitamin C reduces edema, pain, and trismus, and enhances early soft tissue healing compared to placebo.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

The Effect of Supplementary Foods Containing Trypsin, Chymotrypsin and Serratia Peptidase on Healing After Impacted Wisdom Tooth Surgery

NCT07269171

Oral Health Care

NOT_YET_RECRUITING NA

Fruit And Vegetables and OUtcomes After Removal of Impacted TEeth

NCT01145820

Postoperative Morbidity Trauma Wound Healing

COMPLETED NA

The Effect of Saline Irrigation at Different Temperatures on Pain, Edema, and Trismus After Impacted Third Molar Surgery

NCT05170516

Impacted Third Molar Tooth

COMPLETED NA

Effect of Hypochlorous Acid-containing Mouthwash on Healing After Impacted Wisdom Tooth Surgery

NCT06920485

Oral Health

ENROLLING_BY_INVITATION NA

Effect of Post-operative Chlorhexidine on Postoperative Pain and Complications After Surgical Removal of Mandibular Third Molars

NCT06880952

Third Molars Extraction

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

This randomized, split-mouth clinical trial aimed to investigate the effect of oral vitamin C supplementation on postoperative recovery following the surgical extraction of impacted mandibular third molars. A total of 56 healthy patients requiring bilateral lower third molar extractions were included in the study. Each patient underwent two separate surgeries on both sides, with each side randomly assigned to receive either 1000 mg of oral vitamin C or a placebo.

Vitamin C supplementation started one day prior to surgery and continued for seven days postoperatively. The primary outcomes of the study were facial swelling, pain, trismus, and early soft tissue healing. Facial swelling was assessed using three linear measurements between specific anatomical landmarks: tragus-pogonion, tragus-labial commissure, and lateral canthus of the eye-angulus mandible. Trismus was measured based on maximum interincisal distance. Pain was evaluated using the visual analog scale (VAS) on postoperative days 1, 2, and 7. Edema, trismus, and early wound healing were assessed on postoperative days 2 and 7. Early wound healing was scored using the Landry healing index. Analgesic consumption was also recorded during the postoperative period.

This study was designed to evaluate whether vitamin C supplementation could reduce postoperative edema, pain, and trismus, and improve early soft tissue healing in comparison to placebo in the context of oral surgical procedures. The findings may provide evidence to support the use of vitamin C as an adjunctive therapy in oral surgery.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Impacted Mandibular Third Molar

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

This study employed a split-mouth crossover design, where each participant served as their own control. Bilateral surgical extractions of impacted mandibular third molars were performed in two separate sessions. The intervention (vitamin C) and the control (placebo) were randomly assigned to either the left or right surgical site, allowing intra-individual comparison of postoperative outcomes.

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors

This study was designed as a double-blind trial. Both the participants and the outcome assessors were blinded to the allocation of the intervention (vitamin C or placebo). The tablets were identical in appearance, taste, and packaging to ensure blinding integrity. Allocation concealment was maintained by a third party responsible for randomization and distribution of the supplements. The clinical evaluator who performed the postoperative measurements (pain, swelling, trismus, and wound healing) was not informed about the intervention administered to each surgical site. Participants were also unaware of which side received vitamin C or placebo.

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Vitamin C

Patients received 1000 mg of oral vitamin C daily starting one day before surgery through postoperative day 7.

Group Type EXPERIMENTAL

Vitamin C

Intervention Type DIETARY_SUPPLEMENT

1000 mg oral vitamin C tablet taken daily from one day before surgery to postoperative day 7.

Placebo

Patients received an identical-looking placebo tablet once daily for the same duration.

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type OTHER

Identical-appearing oral tablet taken on the same schedule as the vitamin C group.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Vitamin C

1000 mg oral vitamin C tablet taken daily from one day before surgery to postoperative day 7.

Intervention Type DIETARY_SUPPLEMENT

Placebo

Identical-appearing oral tablet taken on the same schedule as the vitamin C group.

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Age 18-35 years
* Systemically healthy
* Non-smoker
* No alcohol or substance abuse
* Bilateral impacted mandibular third molars
* Mesioangular impaction with a Pederson index of 5-6
* Voluntary participation
* Ability and willingness to attend follow-up visits

Exclusion Criteria

* Pregnancy or lactation
* Presence of infection or pain related to third molars
* Associated pathological conditions (e.g., cysts or tumors)
* History of previous mandibular third molar extraction
* Congenital absence of third molars
* Known allergy to any drug or substance used in the study

Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes