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The Use of Manuka Honey to Improve Healing After Third Molars Surgery

NCT ID: NCT02483741

Last Updated: 2016-12-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-06-30

Study Completion Date

2016-11-30

Brief Summary

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Since there is an evidence that Manuka honey is an antibacterial agent, the present study aims to confirm this characteristic and assess its effect in improving healing and reducing postsurgical symptoms, if topically applied after the surgical removal of impacted mandibular third molars

Detailed Description

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Sufficient evidence exists recommending the use of honey in the management of acute wounds and burns. Studies revealed that the healing effect of honey could be classified by its antibacterial, antiviral, anti-inflammatory and antioxidant properties of its components. Manuka honey has been shown to inhibit a wide range of microorganisms, including multiresistant strains. This unique honey is derived from flowers of manuka tree (Leptospermum scoparium) in New Zealand. Dihydroxyacetone and methylglyoxal are unique and naturally occurring constituents of manuka honey that correlate with its antibacterial activity.

Since surgical extraction of impacted molars is one of the most common operations in the oral cavity and the postoperative symptoms disturbing the patient may reduce the quality of health service, this study aims to assess the healing potential of Manuka honey in reducing these symptoms by comparing the outcome of extraction of impacted lower molars with and without topical application of Manuka honey into the extraction socket.

Conditions

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Surgical Extraction of Impacted Third Molars

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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Manuka Honey

Manuka Honey will be placed in the sockets of the extracted third molars in this group

Group Type EXPERIMENTAL

Manuka Honey

Intervention Type BIOLOGICAL

This material is going to be placed into the sockets of the extracted third molars in the experimental group

Traditional Extraction

No any special material will be placed in the sockets of the extracted third molars in this group

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Manuka Honey

This material is going to be placed into the sockets of the extracted third molars in the experimental group

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* Asymptomatic, Symmetrical, Bilateral Impacted Third Molars

Exclusion Criteria

* Uncontrolled diabetes,
* Hypersensitivity to Honey
* Alcoholism,
* Drug abuse,
* Pathological condition in the region
Minimum Eligible Age

20 Years

Maximum Eligible Age

37 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Damascus University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Nuraldeen Al-Khanati, DDS

Role: PRINCIPAL_INVESTIGATOR

MSc student, Oral and Maxillofacial Department, University of Damascus Dental School

Yasser Al-Moudallal, DDS MSc PhD

Role: STUDY_DIRECTOR

Associate Professor of Oral and Maxillofacial Surgery, University of Damascus Dental School

Locations

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Department of Oral and Maxillofacial Surgery, University of Damascus Dental School

Damascus, Damscus, Syria

Site Status

Countries

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Syria

References

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Atrott J, Haberlau S, Henle T. Studies on the formation of methylglyoxal from dihydroxyacetone in Manuka (Leptospermum scoparium) honey. Carbohydr Res. 2012 Nov 1;361:7-11. doi: 10.1016/j.carres.2012.07.025. Epub 2012 Aug 8.

Reference Type BACKGROUND
PMID: 22960208 (View on PubMed)

Mavric E, Wittmann S, Barth G, Henle T. Identification and quantification of methylglyoxal as the dominant antibacterial constituent of Manuka (Leptospermum scoparium) honeys from New Zealand. Mol Nutr Food Res. 2008 Apr;52(4):483-9. doi: 10.1002/mnfr.200700282.

Reference Type BACKGROUND
PMID: 18210383 (View on PubMed)

Rathnam A, Madan N, Madan N. The language of pain: A short study. Contemp Clin Dent. 2010 Jul;1(3):142-5. doi: 10.4103/0976-237X.72778.

Reference Type BACKGROUND
PMID: 22114404 (View on PubMed)

Ruta DA, Bissias E, Ogston S, Ogden GR. Assessing health outcomes after extraction of third molars: the postoperative symptom severity (PoSSe) scale. Br J Oral Maxillofac Surg. 2000 Oct;38(5):480-7. doi: 10.1054/bjom.2000.0339.

Reference Type BACKGROUND
PMID: 11010778 (View on PubMed)

Singh V, Pal US, Singh R, Soni N. Honey a sweet approach to alveolar osteitis: A study. Natl J Maxillofac Surg. 2014 Jan;5(1):31-4. doi: 10.4103/0975-5950.140166.

Reference Type BACKGROUND
PMID: 25298714 (View on PubMed)

Wijesinghe M, Weatherall M, Perrin K, Beasley R. Honey in the treatment of burns: a systematic review and meta-analysis of its efficacy. N Z Med J. 2009 May 22;122(1295):47-60.

Reference Type BACKGROUND
PMID: 19648986 (View on PubMed)

Yaghoobi R, Kazerouni A, Kazerouni O. Evidence for Clinical Use of Honey in Wound Healing as an Anti-bacterial, Anti-inflammatory Anti-oxidant and Anti-viral Agent: A Review. Jundishapur J Nat Pharm Prod. 2013 Aug;8(3):100-4. doi: 10.17795/jjnpp-9487. Epub 2013 Jul 17.

Reference Type BACKGROUND
PMID: 24624197 (View on PubMed)

Other Identifiers

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UDDS-OMFS-04-2015

Identifier Type: -

Identifier Source: org_study_id