Precision Analytic Research Methods in OCD

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-07-09

Study Completion Date

2030-03-31

Brief Summary

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Psychiatric disorders characterized by compulsivity, such as obsessive-compulsive disorder (OCD), result in considerable functional impairment and many individuals do not respond to gold-standard treatments. Compulsivity has long been thought to occur due to exaggerated habits and reduced goal-directed control, although more recently, this conceptualization of compulsivity as an imbalance of two cognitive systems has been challenged as overly narrow. This study will recruit 100 individuals (50 adults diagnosed with OCD, 50 healthy controls) and leverage the measurement precision offered by theory-driven computational modeling in combination with electroencephalogram (EEG) to go beyond this binary theory of compulsivity, revealing how more complex interactions of neurocognitive subcomponents contribute to compulsivity-information that could ultimately lead to improved treatment personalization and clinical outcomes.

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Detailed Description

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Conditions

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Obsessive Compulsive Disorder

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Participants diagnosed with OCD

All participants diagnosed with Obsessive Compulsive Disorder (OCD) who enroll in this study will receive 17 sessions of exposure and response prevention, a specialized cognitive behavioral therapy for OCD, over the course of 10 weeks.

Group Type EXPERIMENTAL

Exposure and Response Prevention

Intervention Type BEHAVIORAL

Exposure and response prevention (EX/RP) is the gold-standard behavioral treatment for OCD. It involves confronting the content of obsessions (distressing thoughts, images, or impulses) and resisting the urge to engage in compulsions (observable behaviors or mental acts that are repeated to reduce the anxiety/distress associated with compulsions).

Healthy controls

Individuals who do not have a current or lifetime psychiatric diagnosis will not receive any treatment.

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Exposure and Response Prevention

Exposure and response prevention (EX/RP) is the gold-standard behavioral treatment for OCD. It involves confronting the content of obsessions (distressing thoughts, images, or impulses) and resisting the urge to engage in compulsions (observable behaviors or mental acts that are repeated to reduce the anxiety/distress associated with compulsions).

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

Participants must be:

* between the ages 18-55 years old
* English-speaking
* right-handed
* able to provide consent

Exclusion Criteria

Individuals diagnosed with OCD will be excluded if:

* they meet diagnostic criteria for certain other psychiatric disorders
* are taking psychiatric medication or have received behavioral treatment for OCD within a certain timeframe
* if it is unsafe for them to participate in research

Healthy control participants will be excluded if:

* they have a current psychiatric disorder
* a lifetime history of certain psychiatric disorders
* are taking psychiatric medication or have in the past
* have a parent or sibling who has been diagnosed with OCD
* if it is unsafe for them to participate in research

Minimum Eligible Age

18 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes