Cerebral and Cognitive Markers of Treatment Resistance in Obsessive Compulsive Disorder

NCT ID: NCT05843604

Last Updated: 2026-01-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

RECRUITING

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-07-03

Study Completion Date

2027-09-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This study aims to define individual profiles of treatment resistants in order to find indicators and predictors of the therapeutic response.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

OCD

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

obsessive compulsive disorder patients

Functional MRI

Intervention Type OTHER

Three cognitive tests will be performed in the MRI, namely a stroop task, an N-back task and a switching task

Control Patients

Functional MRI

Intervention Type OTHER

Three cognitive tests will be performed in the MRI, namely a stroop task, an N-back task and a switching task

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Functional MRI

Three cognitive tests will be performed in the MRI, namely a stroop task, an N-back task and a switching task

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Obsessive compulsive disorder diagnosed according to Diagnostic and Statistical Manual 5 criteria (patients will be included regardless of the severity and resistance of their pathology and their levels of executive functions)
* Understand and accept the constraints of the study
* Be a beneficiary or affiliated to a Health Insurance scheme

Exclusion Criteria

* Present one of the diagnoses according to the criteria of the DSM 5: schizophrenic disorders, substance abuse or dependence to a substance according to the criteria of the M.I.N.I. version 5.0 (Sheehan et al., 1998)
* Have a serious intercurrent pathology
* Being a pregnant woman
* Being a woman of childbearing age without effective contraception.
* Being hospitalized under duress or on an outpatient basis in a care program
* Being under judicial protection (reinforced curatorship, guardianship)
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Centre Hospitalier Henri Laborit

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Centre Hospitalier Henri Laborit

Poitiers, , France

Site Status RECRUITING

Countries

Review the countries where the study has at least one active or historical site.

France

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

Damien Doolub, MD

Role: CONTACT

+33 (0)5 16 61 18

Facility Contacts

Find local site contact details for specific facilities participating in the trial.

Damien Doolub, MD

Role: primary

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

2022-A00463-40

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.