Deep Electrical Neuromodulation in Obsessive-compulsive Disorder

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

6 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-04-01

Study Completion Date

2018-06-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Obsessive-compulsive disorder (OCD) is a neuropsychiatric disease characterised by intrusive, recurrent and persistent thoughts, urges or images (obsessions) and the resulting excessive repetitive behaviours or mental acts according to rigid rules unrealistically aimed at reducing distress (compulsions).

Its lifetime prevalence in the general population is usually estimated between 1 - 3% (Ruscio, Mol Psychiatry, 2010). Despite appropriate pharmacological and cognitive-behavioural treatments, it is commonly estimated that 10% of patients are therapy-refractory and that among improved or recovered patients, sustained efficacy is uncertain.

For treatment refractory OCD patients, a neurosurgical treatment by deep brain stimulation (DBS), has emerged in the late 1990s as a new therapeutic option (Nuttin et al, Lancet, 1999).

The objective of the current study is to report the long-term treatment effects (safety and effectiveness) of DBS from the cohort of six severe and therapy-refractory OCD patients implanted at the French university hospital of Montpellier since 2003.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Comparison of DBS Targets in Obsessive-compulsive Disorder

NCT01807403

Obsessive-Compulsive Disorder

COMPLETED PHASE3

Refining the Target for Deep Brain Stimulation (DBS) in Severe, Treatment Refractory Obsessive Compulsive Disorder (OCD)

NCT01985815

Obsessive-Compulsive Disorder

COMPLETED PHASE1/PHASE2

Evaluating Unilateral Deep Brain Stimulation in Patients With Obsessive Compulsive Disorder

NCT03894397

Obsessive-Compulsive Disorder

COMPLETED NA

European Study of Quality of Life in Resistant OCD Patients Treated by STN DBS

NCT02844049

Obsessive-Compulsive Disorder

RECRUITING NA

Deep Brain Stimulation for Treatment-Resistant Obsessive Compulsive Disorder

NCT00057603

Obsessive-Compulsive Disorder

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The data needed to carry out the study will be extracted from the medical files of the 6 patients concerned.

The following data will be collected:

* Age, sex
* Medical, surgical and psychiatric history
* History of pharmacological treatments
* Elements from clinical examination
* any reported adverse effect
* scores of the various questionnaires completed throughout the follow-up (including Y-BOCS and GAF)
* results of biological, morphological, neuropsychological tests
* Stimulation parameters applied since implantation.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Obsessive-compulsive Disorder (OCD)

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Deep brain stimulation (DBS)

Neurosurgical treatment by stereotactic implantation of electrodes in the brain that affects the functioning of subcortical neuronal circuits

Intervention Type PROCEDURE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* all patients with severe and refractory OCD according to DSM-IV criteria, confirmed by experienced psychiatrist
* treated by DBS at the CHU of Montpellier