Control and Reward Circuits in Obsessive Compulsive Disorder

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

80 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-10-31

Study Completion Date

2018-08-31

Brief Summary

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The purpose of this study is to examine the brain functioning of OCD patients and healthy controls before and after treatment with Exposure and Response Prevention (EXRP) therapy.

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Detailed Description

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The capacity to coordinate thoughts and actions to execute goal-directed behaviors (cognitive control) and the capacity to anticipate, respond to, and learn from reward (reward processing) are key processes for human behavior. Dysfunction in these processes has been hypothesized to contribute to repetitive thoughts and behaviors in many disorders, including obsessive-compulsive disorder (OCD), Tourette Syndrome (TS), and eating disorders. We will use multimodal imaging to investigate neural circuits that support cognitive control and reward processing, using OCD as a model system. The short-term goal is to clarify how circuit-based abnormalities contribute to repetitive thoughts/behaviors; these data will inform future transdiagnostic studies. The long-term goal is to identify control and reward circuit-abnormalities as targets for new transdiagnostic treatments.

Conditions

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Obsessive-Compulsive Disorder

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Patients with OCD

Behavioral: Exposure \& Response Prevention (EX/RP)

Group Type EXPERIMENTAL

Exposure & Response Prevention (EX/RP)

Intervention Type BEHAVIORAL

Exposure and Response Prevention (EX/RP) is a type of Cognitive Behavioral Treatment for treating OCD.

Interventions

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Exposure & Response Prevention (EX/RP)

Exposure and Response Prevention (EX/RP) is a type of Cognitive Behavioral Treatment for treating OCD.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Male and females with OCD aged 18-55
* Diagnostic and Statistical Manual of Mental Disorders (DSM-5) Diagnosis of OCD
* Not on psychotropic medication

\- Male and females aged 18-55

Exclusion Criteria

* Presence of metallic devices or dental braces in the body that are contraindicators for MR imaging
* Comorbid psychiatric conditions that significantly elevate the risk of study participation (e.g. psychotic disorders, bipolar disorder, evidence of dementia or other cognitive disorder, suicidality)
* Unstable medical conditions that need attention and would make participation in the study unsafe (e.g. very high blood pressure)
* Use of psychotropic medication
* Females who are pregnant or post-menopausal

* Presence of metallic devices or dental braces in the body that are contraindicators for MR imaging
* Any psychiatric diagnosis
* Use of psychotropic medication
* Diagnosis of OCD in a first degree relative
* Females who are pregnant or post-menopausal
* Unstable medical conditions that need attention and would make participation in the study unsafe (e.g. very high blood pressure)

Minimum Eligible Age

18 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Responsible Party

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Helen Blair Simpson

Professor of Psychiatry-Columbia University Medical Center, Columbia University; Director of Anxiety Disorders Clinic & Center for OCD and Related Disorders

Responsibility Role PRINCIPAL_INVESTIGATOR