A Study to Evaluate the Long-term Safety, Tolerability, and Efficacy of Subcutaneous Sonelokimab in Participants With Moderate to Severe Hidradenitis Suppurativa

NCT ID: NCT07007637

Last Updated: 2025-09-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ENROLLING_BY_INVITATION

Clinical Phase

PHASE3

Total Enrollment

835 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-06-27

Study Completion Date

2028-06-13

Brief Summary

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This is a study to evaluate the long-term safety, tolerability, and efficacy of sonelokimab in participants with moderate to severe hidradenitis suppurativa who were previously enrolled in a parental study.

Detailed Description

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Conditions

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Hidradenitis Suppurativa

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Experimental: sonelokimab

All participants will receive sonelokimab 120 mg Q4W for up to 2 years

Group Type EXPERIMENTAL

Sonelokimab

Intervention Type DRUG

Sonelokimab

Interventions

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Sonelokimab

Sonelokimab

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Participants who have completed a parental study (M1095-HS-301 or M1095-HS-302 \[adult studies\] or M1095-HS-304 \[adolescent study\]) and are eligible to continue to receive sonelokimab at the time of completing the parental study.
* Female participants are eligible to participate if they are not pregnant or breastfeeding
* Male participants must be willing to use a condom when sexually active with a partner of childbearing potential . Male participants must also agree to refrain from donating sperm during the study and for at least 8 weeks after the last dose of study treatment.

Exclusion Criteria

* Participants who meet any of the discontinuation criteria of the parental study at the time of enrollment in this OLE study.
* Participants who have ongoing or planned to use one or more of the prohibited HS or non-HS treatments specified in the protocol.
* Participants who plan to participate in another interventional study for a drug or device during this study.
Minimum Eligible Age

12 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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MoonLake Immunotherapeutics AG

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Clinical Site

Birmingham, Alabama, United States

Site Status

Clinical Site

Northridge, California, United States

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North Miami Beach, Florida, United States

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Macon, Georgia, United States

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Sandy Springs, Georgia, United States

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Columbus, Indiana, United States

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New Albany, Indiana, United States

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Murray, Kentucky, United States

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Canton, Michigan, United States

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Clarkston, Michigan, United States

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Waterford, Michigan, United States

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New Brighton, Minnesota, United States

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Omaha, Nebraska, United States

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Murfreesboro, Tennessee, United States

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Dallas, Texas, United States

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San Antonio, Texas, United States

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Clinical Site

Fredericton, New Brunswick, Canada

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Barrie, Ontario, Canada

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Guelph, Ontario, Canada

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Markham, Ontario, Canada

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Peterborough, Ontario, Canada

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Toronto, Ontario, Canada

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Clinical Site

Saskatoon, Saskatchewan, Canada

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Countries

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United States Canada

Other Identifiers

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VELA-OLE

Identifier Type: OTHER

Identifier Source: secondary_id

M1095-HS-303

Identifier Type: -

Identifier Source: org_study_id

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