A Study to Evaluate the Efficacy and Safety of AVTX-009 in Patients With Moderate to Severe Hidradenitis Suppurativa

NCT ID: NCT06603077

Last Updated: 2025-11-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

PHASE2

Total Enrollment

250 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-09-16

Study Completion Date

2026-04-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The main purpose of this study is to evaluate the efficacy and safety of AVTX-009 compared with placebo in patients with moderate to severe Hidradenitis Suppurativa (HS).

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

This is a randomized, double-blind, placebo-controlled, parallel-group, Phase 2 study. Patients will be randomized to one of two AVTX-009 dose regimens or matching placebo in a 1:1:1 ratio.

The study will comprise:

1. A Screening Period which will last up to 28 days.
2. A Treatment Period up to 16 weeks.
3. A Follow-up period of 6 weeks after the last dose of study drug.

The maximum clinical trial duration for each participant is 24 weeks.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Hidradenitis Suppurativa

Keywords

Explore important study keywords that can help with search, categorization, and topic discovery.

Hidradenitis Suppurativa HS acne inversa AVTX-009 LY2189102 FL-101

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

AVTX-009 Regimen 1

Patients will receive AVTX-009 regimen 1.

Group Type EXPERIMENTAL

AVTX-009 Regimen 1

Intervention Type DRUG

AVTX-009 will be administered as a subcutaneous injection every 4 weeks.

AVTX-009 Regimen 2

Patients will receive AVTX-009 regimen 2.

Group Type EXPERIMENTAL

AVTX-009 Regimen 2

Intervention Type DRUG

AVTX-009 will be administered as a subcutaneous injection every 2 weeks.

Placebo

Patients will receive matching placebo.

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Matching placebo will be administered as a subcutaneous injection every 2 weeks.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

AVTX-009 Regimen 1

AVTX-009 will be administered as a subcutaneous injection every 4 weeks.

Intervention Type DRUG

AVTX-009 Regimen 2

AVTX-009 will be administered as a subcutaneous injection every 2 weeks.

Intervention Type DRUG

Placebo

Matching placebo will be administered as a subcutaneous injection every 2 weeks.

Intervention Type DRUG

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

1. Signs and symptoms of hidradenitis suppurativa (HS) for at least 6 months prior to Screening.
2. At least 5 inflammatory lesions in at least 2 distinct anatomical areas, at least 1 of which is Hurley Stage 2 or 3.

Exclusion Criteria

1. Has a draining fistula count of ≥ 20.
2. Has another active skin inflammatory condition, infection (viral, bacterial, or fungal), or another active ongoing inflammatory disease (other than HS) that requires treatment with a prohibited medication, which could interfere with the assessment of HS.
3. History of chronic or recurrent infectious disease, including but not limited to chronic renal infection, chronic lung infection, recurrent urinary tract infection, or open, draining or infected skin wounds or ulcers (not related to HS).
4. Has severe, progressive and/or uncontrolled renal, hepatic, hematologic, endocrine, pulmonary, cardiac, neurologic or immunosuppressive disease.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Avalo Therapeutics, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Clinical Site 1022

Scottsdale, Arizona, United States

Site Status

Clinical Site 1037

Scottsdale, Arizona, United States

Site Status

Clinical Site 1026

Tucson, Arizona, United States

Site Status

Clinical Site 1032

Northridge, California, United States

Site Status

Clinical Site 1019

Pomona, California, United States

Site Status

Clinical Site 1009

Sacramento, California, United States

Site Status

Clinical Site 1034

Santa Monica, California, United States

Site Status

Clinical Site 1011

Washington D.C., District of Columbia, United States

Site Status

Clinical Site 1029

Boca Raton, Florida, United States

Site Status

Clinical Site 1002

Coral Gables, Florida, United States

Site Status

Clinical Site 1015

Maitland, Florida, United States

Site Status

Clinical Site 1027

North Miami Beach, Florida, United States

Site Status

Clinical Site 1013

Tampa, Florida, United States

Site Status

Clinical Site 1008

Savannah, Georgia, United States

Site Status

Clinical Site 1014

Chicago, Illinois, United States

Site Status

Clinical Site 1028

West Lafayette, Indiana, United States

Site Status

Clinical Site 1031

Bowling Green, Kentucky, United States

Site Status

Clinical Site 1024

Murray, Kentucky, United States

Site Status

Clinical Site 1042

Boston, Massachusetts, United States

Site Status

Clinical Site 1001

Boston, Massachusetts, United States

Site Status

Clinical Site 1030

Detroit, Michigan, United States

Site Status

Clinical Site 1007

Fort Gratiot, Michigan, United States

Site Status

Clinical Site 1041

Oakland, Michigan, United States

Site Status

Clinical Site 1003

Portsmouth, New Hampshire, United States

Site Status

Clinical Site 1036

Brooklyn, New York, United States

Site Status

Clinical Site 1016

New York, New York, United States

Site Status

Clinical Site 1023

The Bronx, New York, United States

Site Status

Clinical Site 1020

Cincinnati, Ohio, United States

Site Status

Clinical Site 1010

Cleveland, Ohio, United States

Site Status

Clinical Site 1017

Dublin, Ohio, United States

Site Status

Clinical Site 1004

Philadelphia, Pennsylvania, United States

Site Status

Clinical Site 1035

Pittsburgh, Pennsylvania, United States

Site Status

Clinical Site 1018

Johnston, Rhode Island, United States

Site Status

Clinical Site 1025

Providence, Rhode Island, United States

Site Status

Clinical Site 1005

Greenville, South Carolina, United States

Site Status

Clinical Site 1012

Arlington, Texas, United States

Site Status

Clinical Site 1203

Darlinghurst, New South Wales, Australia

Site Status

Clinical Site 1201

Westmead, New South Wales, Australia

Site Status

Clinical Site 1204

Woolloongabba, Queensland, Australia

Site Status

Clinical Site 1202

Carlton, Victoria, Australia

Site Status

Clinical Site 1303

Sofia, Sofia-Grad, Bulgaria

Site Status

Clinical Site 1302

Lovech, , Bulgaria

Site Status

Clinical Site 1301

Pleven, , Bulgaria

Site Status

Clinical Site 1304

Stara Zagora, , Bulgaria

Site Status

Clinical Site 1105

Edmonton, Alberta, Canada

Site Status

Clinical Site 1108

Edmonton, Alberta, Canada

Site Status

Clinical Site 1103

Barrie, Ontario, Canada

Site Status

Clinical Site 1104

Hamilton, Ontario, Canada

Site Status

Clinical Site 1107

London, Ontario, Canada

Site Status

Clinical Site 1106

Toronto, Ontario, Canada

Site Status

Clinical Site 1110

Montreal, Quebec, Canada

Site Status

Clinical Site 1101

Saskatoon, Saskatchewan, Canada

Site Status

Clinical Site 1111

Québec, , Canada

Site Status

Clinical Site 1401

Prague, Prague, Czechia

Site Status

Clinical Site 1402

Prague, Prague, Czechia

Site Status

Clinical Site 1503

Antony, Hauts-de-Seine, France

Site Status

Clinical Site 1505

Amiens, Picardie, France

Site Status

Clinical Site 1502

Lyon, Rhône, France

Site Status

Clinical Site 1501

Rouen, Seine-Maritime, France

Site Status

Clinical Site 1504

Paris, Île-de-France Region, France

Site Status

Clinical Site 1606

Erlangen, Bavaria, Germany

Site Status

Clinical Site 1604

Frankfurt am Main, Hesse, Germany

Site Status

Clinical Site 1601

Bochum, North Rhine-Westphalia, Germany

Site Status

Clinical Site 1602

Münster, North Rhine-Westphalia, Germany

Site Status

Clinical Site 1605

Dresden, Saxony, Germany

Site Status

Clinical Site 2103

Athens, Attica, Greece

Site Status

Clinical Site 2101

Athens, Attica, Greece

Site Status

Clinical Site 2102

Efkarpia, Thessaloniki, Greece

Site Status

Clinical Site 1901

Torrette, Ancona, Italy

Site Status

Clinical Site 1903

Rozzano, Milano, Italy

Site Status

Clinical Site 1902

Ferrara, , Italy

Site Status

Clinical Site 1908

Milan, , Italy

Site Status

Clinical Site 1906

Pisa, , Italy

Site Status

Clinical Site 1907

Roma, , Italy

Site Status

Clinical Site 1904

Roma, , Italy

Site Status

Clinical Site 1702

Wroclaw, Kuyavian-Pomeranian Voivodeship, Poland

Site Status

Clinical Site 1706

Wroclaw, Lower Silesian Voivodeship, Poland

Site Status

Clinical Site 1703

Bialystok, Podlaskie Voivodeship, Poland

Site Status

Clinical Site 1701

Warszawa, Pomeranian Voivodeship, Poland

Site Status

Clinical Site 1705

Warszawa, Pomeranian Voivodeship, Poland

Site Status

Clinical Site 1704

Ossy, Silesian Voivodeship, Poland

Site Status

Clinical Site 2202

Svidník, Presov, Slovakia

Site Status

Clinical Site 2201

Trnava, Trnava Region, Slovakia

Site Status

Clinical Site 1801

Manises, Valencia, Spain

Site Status

Clinical Site 1802

Granada, , Spain

Site Status

Clinical Site 1803

Madrid, , Spain

Site Status

Clinical Site 1804

Seville, , Spain

Site Status

Clinical Site 2001

Gaziantep, , Turkey (Türkiye)

Site Status

Clinical Site 2002

Samsun, , Turkey (Türkiye)

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States Australia Bulgaria Canada Czechia France Germany Greece Italy Poland Slovakia Spain Turkey (Türkiye)

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

AVTX-009-HS-201

Identifier Type: -

Identifier Source: org_study_id