Effects of LPG and Ventilation Interventions on Reducing HAP and Improving Cardiopulmonary Health

NCT ID: NCT07005193

Last Updated: 2025-06-05

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Clinical Phase: NA
• Total Enrollment: 600 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-06-01
• Study Completion Date: 2029-06-30

Brief Summary

The goal of this clinical trial is to evaluate the independent and synergistic effects of liquefied petroleum gas (LPG) substitution and improved ventilation on household air pollution (HAP) reduction and cardiopulmonary health. The main questions it aims to answer are:

1. Does LPG substitution or improved ventilation reduce HAP and improve cardiopulmonary health?

2. Would the combined intervention of LPG substitution and improved ventilation outperform single interventions?

3. What is the cost-effectiveness of such interventions, and are they sustainable?

Participants will be randomized in 4 groups:

A: Solid fuel + no ventilation facilities group (150 households): Continued use of solid fuels without ventilation facilities, with a one-time financial compensation provided post-intervention; B: Liquefied petroleum gas (LPG) + no ventilation facilities group (150 households): Provided with LPG stoves and instructed to use them for cooking, with regular LPG supply during the intervention period; C: Solid fuel + ventilation facilities group (150 households): Maintained solid fuel usage habits while provided with ventilation facilities and instructed to use them during cooking, with electricity costs compensated during the intervention; D: LPG + ventilation facilities group (150 households): Provided with both LPG stoves and ventilation facilities, instructed to use both during cooking, with regular LPG supply and electricity cost compensation throughout the intervention period.

Conditions

Cardiopulmonary Function; Environmental Exposures

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: FACTORIAL
• Primary Study Purpose: PREVENTION
• Blinding Strategy: NONE

Study Groups

A: Solid fuel + no ventilation (control).

Solid fuel + no ventilation facilities group: Continued use of solid fuels without ventilation facilities, with a one-time financial compensation provided post-intervention.

Group Type: NO_INTERVENTION

No interventions assigned to this group

B: LPG + no ventilation.

Liquefied petroleum gas (LPG) + no ventilation facilities group: Provided with LPG stoves and instructed to use them for cooking, with regular LPG supply during the intervention period.

Group Type: EXPERIMENTAL

Using liquefied gas for cooking

Intervention Type: BEHAVIORAL

Using liquefied gas instead of solid fuels for cooking

C: Solid fuel + ventilation.

Solid fuel + ventilation facilities group: Maintained solid fuel usage habits while provided with ventilation facilities and instructed to use them during cooking, with electricity costs compensated during the intervention.

Group Type: EXPERIMENTAL

Using rang hood during cooking

Intervention Type: DEVICE

Cooking ventilation facilities

D: LPG + ventilation.

LPG + ventilation facilities group: Provided with both LPG stoves and ventilation facilities, instructed to use both during cooking, with regular LPG supply and electricity cost compensation throughout the intervention period.

Group Type: EXPERIMENTAL

Using rang hood during cooking

Intervention Type: DEVICE

Cooking ventilation facilities

Using liquefied gas for cooking

Intervention Type: BEHAVIORAL

Using liquefied gas instead of solid fuels for cooking

Interventions

Using rang hood during cooking

Cooking ventilation facilities

Intervention Type: DEVICE

Using liquefied gas for cooking

Using liquefied gas instead of solid fuels for cooking

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• Primary use of solid fuels (coal, wood, charcoal, or crop residues) for cooking;
• Kitchen is suitable for installing ventilation facilities;
• The main cook in the household (cooking frequency ≥5 times/week);
• Aged between 18 and 74 years;
• Local permanent residents with no plans for long-term travel or relocation within one year.

Secondary Participants

● Elderly individuals aged 65-74 who lived with the included primary participants.

Exclusion Criteria

• Clinical diagnosis of major chronic diseases such as severe respiratory diseases, cardiovascular diseases, malignant tumors, or end-stage renal disease;
• Pregnant or breastfeeding women;
• Current smokers or individuals with self-reported exposure to productive dust or other occupational hazards;
• Individuals who are unable to fully understand the study process or clearly express their own complaints, such as those with psychiatric disorders or severe neuroses, or who cannot cooperate with the study for other reasons.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Huazhong University of Science and Technology

OTHER

Sponsor Role: lead

Responsible Party

Kuai Yu

Associate Research Fellow, Principal Investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Kuai Yu

Role: PRINCIPAL_INVESTIGATOR

Huazhong University of Science and Technology

Central Contacts

Kuai Yu

Role: CONTACT

yukuai5200@163.com

+86 15172473088

Hao Wang

Role: CONTACT

wanghaogongwei@163.com

+8618623910286

Other Identifiers

2023ZD0509902

Identifier Type: -

Identifier Source: org_study_id