ArtiBest for Knee Osteoarthritis

NCT ID: NCT06994546

Last Updated: 2025-05-29

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: NA
• Total Enrollment: 60 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-03-11
• Study Completion Date: 2026-04-30

Brief Summary

The goal of this clinical trial is to evaluate the real-world effectiveness and safety of ArtiBest in the treatment of knee osteoarthritis. The main questions it aims to answer are:

1. The change from baseline The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain score at 26 weeks post injection.

2. The change from baseline VAS resting pain score at 12 and 26 weeks post injection.

3. The change from baseline The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain score at 12 weeks post injection.

4. The change from baseline Patient's Global Assessment PGA) using VAS scoring at 12 and 26 weeks post injection.

5. The OMERACT OARSI responder rate at 12 and 26 weeks post injection.

6. The VAS satisfaction score at 12 and 26 weeks post injection

7. The incidence of Adverse events reported during the study period.

Participants will undergo a single injection of ArtiBest at treatment visit, and three follow up visits at week 4 , 12 , and 26.

Detailed Description

This single center, single arm, open label, interventional study aims to assess the effectiveness and the safety profiles of ArtiBest ® Intra articular Injection(MAXIGEN BIOTECH INC., Taiwan). It plans to enroll approximately 60 eligible patients to receive a 3 ml single pre-filled syringe per knee joint at the treatment visit. Each syringe contains 20 mg/mL sodium hyaluronate. Follow-up visits will be at 4 weeks(a telephone contact by the investigator), 12 weeks and 26 weeks after the injections. All endpoints are planning to evaluate the change between baseline(pre-treatment) and 12 and 26 weeks post-injection. The OMERACT-OARSI responder rate will also be calculated. And the exploratory endpoints will evaluate the change in the range of motion (ROM) at 12 and 26 weeks post-injection. Additionally, the Kellgren-Lawrence grade (KL grade) at baseline and 26 weeks, as well as the target joint space at baseline and 26weeks, will also be analyzed. In general, the change from the baseline of continuous data will be performed by paired t-test or Wilcoxon signed-rank test. The statistical analysis for primary endpoint will be one-sided under a significance level of 0.025. Unless otherwise specified, other statistical analysis will be two-sided under a significance level of 0.05.

Conditions

Knee Osteoarthristis

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

AB

Group Type: EXPERIMENTAL

ArtiBest ® Intra articular Injection

Intervention Type: DEVICE

single intra articular injection of 3 ml (one syringe) per knee joint. Each syringe contains 20 mg/mL sodium hyaluronate.

Interventions

ArtiBest ® Intra articular Injection

single intra articular injection of 3 ml (one syringe) per knee joint. Each syringe contains 20 mg/mL sodium hyaluronate.

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

• Age from 35 to 85 years.
• Subject with x ray imaging evidence of knee OA as Kellgren Lawrence grade = 2 or 3 within 1 month at screening.
• Subject diagnosed with mild to moderate knee OA, particularly in patients who failed to respond adequately to conservative nonpharmacologic therapies or analgesics.
• Subject with a 100 mm VAS resting pain score ≥ 30 mm in the studied knee at both the screening and treatment visit (screening visit and treatment visit can be on the same day)
• Able and willing to comply with all study visits and procedures.
• Willin g and capable of providing written informed consent.

Exclusion Criteria

• Subjects with known hypersensitivity to hyaluronate.
• Subjects with infections or skin diseases in the area of the injection site.
• Pregnancy or breast feeding woman.
• Joining other interventional trial s within 3 months prior to injecting this study product
• Subject receive an intra articular (IA) injection of Hyaluronic Acid (HA) and/or steroid in target knee within 6 months prior to the trial
• Subjects with rheumatoid arthritis
• Any surgery to the target knee within the 12 months prior to the trial, or surgery to the contralateral knee or other weight bearing joint if it will interfere with knee assessments

• Minimum Eligible Age: 35 Years
• Maximum Eligible Age: 85 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Maxigen Biotech Inc.

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Kaohsiung Chang Gung Memorial Hospital

Kaohsiung City, , Taiwan

Site Status: RECRUITING

Countries

Taiwan

Central Contacts

Chen

Role: CONTACT

lirong.chen@mbi.com.tw

+88633287222 ext. 1250

Facility Contacts

Doctor Wu

Role: primary

ray4595@gmail.com

+886-7-7317-123 ext. 8003

Other Identifiers

MBI-AB-202408

Identifier Type: -

Identifier Source: org_study_id