Therapeutic Effect of Oral Hyaluronic Acid on Knee Osteoarthritis
NCT ID: NCT07033312
Last Updated: 2025-06-24
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
40 participants
INTERVENTIONAL
2023-04-21
2025-08-31
Brief Summary
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Participants will receive a total of three months of oral hyaluronate or placebo agents.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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oral hyaluronate plus hyaluronate knee injection
oral hyaluronate plus hyaluronate knee injection
oral hyaluronate and injection
The patient receives oral hyaluronate and hyaluronate injection
hyaluronate knee injection
hyaluronate knee injection
hyaluronate injection
The patient receives hyaluronate injection only
Interventions
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oral hyaluronate and injection
The patient receives oral hyaluronate and hyaluronate injection
hyaluronate injection
The patient receives hyaluronate injection only
Eligibility Criteria
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Inclusion Criteria
2. Had knee effusion at the suprapatellar recess under ultrasonographic examination.
3. Age between 60 and 75 years old.
Exclusion Criteria
2. Accidental trauma or fractures involving knees in the past three months
3. Neuropathic pain involving lower limbs
4. Central nervous system disorders including stroke, Parkinsonism, and spinal cord disorders.
5. Depression and cognitive problems
6. Pregnancy
60 Years
75 Years
ALL
No
Sponsors
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Taichung Veterans General Hospital
OTHER
Responsible Party
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Locations
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Taichung Veterans General Hospital
Taichung, Taiwan, Taiwan
Countries
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Central Contacts
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Facility Contacts
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References
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Nelson FR, Zvirbulis RA, Zonca B, Li KW, Turner SM, Pasierb M, Wilton P, Martinez-Puig D, Wu W. The effects of an oral preparation containing hyaluronic acid (Oralvisc(R)) on obese knee osteoarthritis patients determined by pain, function, bradykinin, leptin, inflammatory cytokines, and heavy water analyses. Rheumatol Int. 2015 Jan;35(1):43-52. doi: 10.1007/s00296-014-3047-6. Epub 2014 Jun 5.
Other Identifiers
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SF22377A
Identifier Type: -
Identifier Source: org_study_id
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