Effect of Platelet-rich Plasma (PRP) Injection on Knee Osteoarthritis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

300 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-09-01

Study Completion Date

2025-12-31

Brief Summary

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To evaluate the safety and effectiveness of PRP injection therapy in the repair of osteoarthritis and periarticular soft tissue injury through a single-center, exploratory clinical study, and to provide a more reliable basis for the treatment of joint injury.

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Detailed Description

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Conditions

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Platelets-rich Plasma Osteoarthritis Knees Both Meniscus Disorder Cartilage Injury

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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Preoperative

Group Type NO_INTERVENTION

No interventions assigned to this group

postoperative (6 weeks)

The patients were injected with PRP.

Group Type EXPERIMENTAL

Sodium hyaluronate injection

Intervention Type DRUG

The control group was injected into the joint cavity with sodium hyaluronate injection..

postoperative (3 months)

The patients were injected with PRP.

Group Type EXPERIMENTAL

Sodium hyaluronate injection

Intervention Type DRUG

The control group was injected into the joint cavity with sodium hyaluronate injection..

Interventions

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Sodium hyaluronate injection

The control group was injected into the joint cavity with sodium hyaluronate injection..

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* The age range of the participants was 20 to 60 years old. Through a comprehensive clinical and imaging examination, it was conclusively determined that the individuals had knee osteoarthritis or experienced injuries to the cart, and meniscus surrounding the knee joint.
* The preoperative routine tests and examinations revealed no contraindications.
* Revised sentence: "Informed consent of the patient

Exclusion Criteria

* The platelet count or function exhibits significant abnormalities、Systemic infection transmitted through the bloodstream.
* Prolonged usage of anti-inflammatory drugs and systemic corticoid administration.
* In injection site or damage to the skin.
* Patients with tumors or undergoing radiotherapy and chemotherapy.
* Pregnant or breastfeeding women.
* Individuals with mental illnesses who are unable to cooperate with follow-up procedures.
* Contraindications for MRI、Patients or their families do consent to participate in the study.
* Other circumstances that render participation in the study unsuitable.

Minimum Eligible Age

20 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No