Additional Effects of Steroid and Dextrose to Hyaluronic Acid on Knee Osteoarthritis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Clinical Phase

PHASE4

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-11-11

Study Completion Date

2020-07-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Using double-blind, randomized controlled design to compare the immediate, short-term and intermediate-term additional therapeutic effects of ultrasound-guided corticosteroid injection and dextrose injection of hyaluronic acid injection on patients with knee osteoarthritis, under the basis of International Classification of Functioning, Disability, and Health.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Effects of Knee Injections on Patients With Knee Osteoarthritis

NCT05220527

Knee Osteoarthritis Injection Effect of Drug

UNKNOWN PHASE4

Effects of Hyaluronic Acid vs. Hyaluronic Acid on Knee Osteoarthritis

NCT02625727

Physical Activity

UNKNOWN PHASE4

Additional Effects of Triamcinolone to Hyaluronic Acid on Knee Osteoarthritis

NCT02949466

Physical Activity Functional Performance

UNKNOWN PHASE4

Effects of Dextrose on Knee Osteoarthritis

NCT03238183

Physical Activity Functional Disturbance

UNKNOWN PHASE4

Efficacy of Hyaluronic Acid Injection in Knee Osteoarthritis

NCT06279507

Knee Osteoarthritis Pain, Joint Stiffness of Knee, Not Elsewhere Classified +1 more

RECRUITING PHASE4

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

A total of 60 patients will be collected. The participants will be randomized into two groups, including hyaluronic acid combined corticosteroid group and hyaluronic acid combined dextrose group. The balance, physical activity (10 meters normal and fast walk, up and downstairs, and 5 repeated chair-rising time, timed up and go test), functional performance and knee-related quality of life (Western Ontario and McMaster Universities Osteoarthritis index、Knee Injury and Osteoarthritis Outcome Score) will be evaluated. All the evaluations will be re-evaluated at one week after injection, one month after injection, three months after injection, and six months after injection. Subjects and evaluators will be both blinded to the group's classification during the whole course of study.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Knee Osteoarthritis

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

steroid plus hyaluronic acid

steroid plus hyaluronic acid injection, one time per week, for 3 weeks

Group Type EXPERIMENTAL

compare the effects of steroid plus hyaluronic acid and destrose plus hyaluronic acid on knee osteroarthritis

Intervention Type DRUG

compare the immediate effect (one week after 3 times of injections), short-term effects (one month and three months after 3 times of injections), and midterm effect (6 months after 3 times of injections).

dextrose plus hyaluronic acid

dextrose plus hyaluronic acid injection, one time per week, for 3 weeks

Group Type ACTIVE_COMPARATOR

compare the effects of steroid plus hyaluronic acid and destrose plus hyaluronic acid on knee osteroarthritis

Intervention Type DRUG

compare the immediate effect (one week after 3 times of injections), short-term effects (one month and three months after 3 times of injections), and midterm effect (6 months after 3 times of injections).

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

compare the effects of steroid plus hyaluronic acid and destrose plus hyaluronic acid on knee osteroarthritis

compare the immediate effect (one week after 3 times of injections), short-term effects (one month and three months after 3 times of injections), and midterm effect (6 months after 3 times of injections).

Intervention Type DRUG

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* clinical diagnosis of knee osteoarthritis can walk for 15 meters Kellgren-Lawerence grade 2 or greater than 2 can follow up for 6 months

Exclusion Criteria

* major diseases will affect balance, such as stroke, infectious diseases, rheumatoid arthritis, dizziness, or vertigo fractures malignance pregnancy or prepare to pregnant received knee injections in the past 6 months previous operation of knee joints

Minimum Eligible Age

40 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No