Functional and Clinical Outcomes of Hyaluronic Acid and Steroid Injections in Bilateral Knee Osteoarthritis
NCT ID: NCT06717529
Last Updated: 2024-12-05
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE4
65 participants
INTERVENTIONAL
2023-01-01
2024-09-30
Brief Summary
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Detailed Description
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Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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Hyaluronic acid injection
This arm will receive a hyaluronic acid injection in the knee joint.
Sodium hyaluronate (hyaluronic acid)
The patient will receive one 3mL Sodium Hyaluronate injection containing 75 mg of active substance in one knee joint.
Steroid injection
This arm will receive steroid injection in the knee joint.
Methylprednisolone Acetate Injection
The patient will receive 2mL of methylprednisolone acetate solution containing 80 mg of the medicine in other knee joint.
Interventions
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Sodium hyaluronate (hyaluronic acid)
The patient will receive one 3mL Sodium Hyaluronate injection containing 75 mg of active substance in one knee joint.
Methylprednisolone Acetate Injection
The patient will receive 2mL of methylprednisolone acetate solution containing 80 mg of the medicine in other knee joint.
Eligibility Criteria
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Inclusion Criteria
* same grade of osteoarthritis in both knees
* Kellgren-Lawrence grade 2 or 3 of knee osteoarthritis
* fully completed all follow-up examinations
Exclusion Criteria
* different grade of osteoarthritis between knees based on Kellgren-Lawrence scale
* positive history of previous knee interventions (injections, surgery)
* positive history of additional knee injuries (meniscus, ligament...)
18 Years
ALL
No
Sponsors
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Edin Mešanović
OTHER
Responsible Party
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Edin Mešanović
Orthopedic surgeon
Locations
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Cantonal Hospital "dr.Safet Mujic"
Mostar, , Bosnia and Herzegovina
Countries
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References
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Ko NY, Chang CN, Cheng CH, Yu HK, Hu GC. Comparative Effectiveness of Focused Extracorporeal versus Radial Extracorporeal Shockwave Therapy for Knee Osteoarthritis-Randomized Controlled Study. Int J Environ Res Public Health. 2022 Jul 24;19(15):9001. doi: 10.3390/ijerph19159001.
Mitra, S., Seenappa, H., & Madhavan, P. (2021). A clinical evaluation study of single spin vs double spin intra-articular prp injection in patients with bilateral early oa knee: a novel technique. International Journal of Orthopaedics Sciences, 7(3), 01-06. https://doi.org/10.22271/ortho.2021.v7.i3a.2718
Rahman, S., Narhari, P., Sharifudin, M., & Aa, S. (2020). Western ontario and mcmaster universities (womac) osteoarthritis index as an assessment tool to indicate total knee arthroplasty in patients with primary knee osteoarthritis. Iium Medical Journal Malaysia, 19(3). https://doi.org/10.31436/imjm.v19i3.1664
Wang SZ, Wu DY, Chang Q, Guo YD, Wang C, Fan WM. Intra-articular, single-shot co-injection of hyaluronic acid and corticosteroids in knee osteoarthritis: A randomized controlled trial. Exp Ther Med. 2018 Sep;16(3):1928-1934. doi: 10.3892/etm.2018.6371. Epub 2018 Jun 29.
Metcalfe AJ, Andersson ML, Goodfellow R, Thorstensson CA. Is knee osteoarthritis a symmetrical disease? Analysis of a 12 year prospective cohort study. BMC Musculoskelet Disord. 2012 Aug 22;13:153. doi: 10.1186/1471-2474-13-153.
Khalaj N, Abu Osman NA, Mokhtar AH, George J, Abas WA. Effect of intra-articular hyaluronic injection on postural stability and risk of fall in patients with bilateral knee osteoarthritis. ScientificWorldJournal. 2014;2014:815184. doi: 10.1155/2014/815184. Epub 2014 Jun 19.
Cotofana S, Wirth W, Pena Rossi C, Eckstein F, Gunther OH. Contralateral knee effect on self-reported knee-specific function and global functional assessment: data from the Osteoarthritis Initiative. Arthritis Care Res (Hoboken). 2015 Mar;67(3):374-81. doi: 10.1002/acr.22495.
Other Identifiers
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01-1-1-5469/23-01
Identifier Type: -
Identifier Source: org_study_id