Intraarticular Injections of the Hip and Knee With Triamcinolone Versus Ketorolac: A Randomized Controlled Trial

NCT ID: NCT04441112

Last Updated: 2020-06-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2/PHASE3

Total Enrollment

120 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-05-20

Study Completion Date

2019-08-20

Brief Summary

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Clinicians commonly utilize intraarticular injections to treat symptomatic primary arthritis. Steroid injections are common yet have immune-modulating effects and can alter gene expression which may delay definitive arthroplasty and further damage cartilage. Non-steroidal anti-inflammatory (NSAID) injections may offer a safer profile due to their differing mechanism of action; however, there is a relative dearth of information regarding their efficacy. This non-inferiority study compares the effectiveness of triamcinolone versus ketorolac in treating symptoms of moderate to advanced primary osteoarthritis of the hip and knee.

Detailed Description

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Conditions

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Arthritis Knee Arthritis of Hip

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Caregivers Investigators

Study Groups

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Ketorolac Intraarticular Hip Injection

Patients will receive an intraarticular hip injection with ketorolac.

Group Type EXPERIMENTAL

Ketorolac Intraarticular Injection

Intervention Type DRUG

Injections will be given under ultrasound guidance with one of two possible medications.

Triamcinolone Intraarticular Hip Injection

Patients will receive an intraarticular hip injection with triamcinolone.

Group Type ACTIVE_COMPARATOR

Triamcinolone Intraarticular Injection

Intervention Type DRUG

Injections will be given under ultrasound guidance with one of two possible medications.

Ketorolac Intraarticular Knee Injection

Patients will receive an intraarticular knee injection with ketorolac.

Group Type EXPERIMENTAL

Ketorolac Intraarticular Injection

Intervention Type DRUG

Injections will be given under ultrasound guidance with one of two possible medications.

Triamcinolone Intraarticular Knee Injection

Patients will receive an intraarticular knee injection with triamcinolone.

Group Type ACTIVE_COMPARATOR

Triamcinolone Intraarticular Injection

Intervention Type DRUG

Injections will be given under ultrasound guidance with one of two possible medications.

Interventions

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Ketorolac Intraarticular Injection

Injections will be given under ultrasound guidance with one of two possible medications.

Intervention Type DRUG

Triamcinolone Intraarticular Injection

Injections will be given under ultrasound guidance with one of two possible medications.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Symptomatic, radiographically proven degenerative joint disease in the hip or knee

Exclusion Criteria

* recent injection in the hip or knee within the previous 3 months
* history of traumatic osteoarthritis or ligamentous reconstruction
* chronic narcotic use
* history of inflammatory or neuropathic arthropathy
* pregnant and/or nursing women
* allergy or strong reaction to study medications
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Saint Alphonsus Regional Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Kevin Jurgensmeier

Medical Student

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Kevin Jurgensmeier, BS

Role: PRINCIPAL_INVESTIGATOR

Student Investigator at Saint Alphonsus Regional Medical Center

Steven B Daines, MD

Role: STUDY_CHAIR

Surgeon at Saint Alphonsus Regional Medical Center

Locations

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Saint Alphonsus Regional Medical Center

Boise, Idaho, United States

Site Status

Countries

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United States

References

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Jurgensmeier K, Jurgensmeier D, Kunz DE, Fuerst PG, Warth LC, Daines SB. Intra-articular Injections of the Hip and Knee With Triamcinolone vs Ketorolac: A Randomized Controlled Trial. J Arthroplasty. 2021 Feb;36(2):416-422. doi: 10.1016/j.arth.2020.08.036. Epub 2020 Aug 22.

Reference Type DERIVED
PMID: 32950343 (View on PubMed)

Other Identifiers

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SaintAlphonsusRMC

Identifier Type: -

Identifier Source: org_study_id

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